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Development of a new class of PSMA radioligands comprising ibuprofen as an albumin-binding entity
177Lu-Ibu-DAB-PSMA, in which ibuprofen was conjugated via a positively-charged diaminobutyric acid (DAB) entity, showed distinguished tumor uptake and the most favorable tumor- to-blood and tumor-to-kidney ratios. Expand
Synthesis, Radiolabeling, and Characterization of Plasma Protein-Binding Ligands: Potential Tools for Modulation of the Pharmacokinetic Properties of (Radio)Pharmaceuticals.
- C. Müller, R. Farkas, F. Borgna, Raffaella M. Schmid, M. Benešová, R. Schibli
- Chemistry, Medicine
- Bioconjugate chemistry
- 12 September 2017
Three different plasma protein binders that are potentially useful in combination with (radio)pharmaceuticals to enhance their half-life in the blood are evaluated and confirmed the high affinity of the 4-(4-iodophenyl)-butyric acid entity (PPB-01) to plasma proteins, while replacement of the halogen by an ethynyl entity ( PPB-02) reduced the plasma protein binding significantly. Expand
A preliminary study for the production of high specific activity radionuclides for nuclear medicine obtained with the isotope separation on line technique.
- F. Borgna, M. Ballan, +8 authors A. Andrighetto
- Chemistry, Medicine
- Applied radiation and isotopes : including data…
- 1 September 2017
Stable ion beams of strontium, yttrium and iodine were produced using the SPES test bench (Front-End) to simulate the production of 89Sr, 90Y, 125I and 131I and collected with good efficiency on suitable targets. Expand
Spes: An intense source of Neutron-Rich Radioactive Beams at Legnaro
The Isotope Separation On-Line (ISOL) method for the production of Radioactive Ion Beams (RIB) is attracting significant interest in the worldwide nuclear physics community. Within this context the… Expand
The RIB production target for the SPES project
Facilities making use of the Isotope Separator On-Line (ISOL) method for the production of Radioactive Ion Beams (RIB) attract interest because they can be used for nuclear structure and reaction… Expand
Early Evaluation of Copper Radioisotope Production at ISOLPHARM
A case study for such project is the evaluation of the feasibility of the ISOL production of 64Cu and 67Cu using a zirconium germanide target, currently under development. Expand
The ISOLPHARM project: ISOL-based production of radionuclides for medical applications
- A. Andrighetto, M. Tosato, +5 authors N. Realdon
- Environmental Science
- Journal of Radioanalytical and Nuclear Chemistry
- 1 October 2019
Radionuclides for radiopharmaceuticals can be produced in cyclotrons or nuclear reactors. Each of these production modes has serious issues, such as high target costs, production of long-lived wastes… Expand
Therapeutic Potential of 47Sc in Comparison to 177Lu and 90Y: Preclinical Investigations
Based on the decay properties and results, 47Sc is likely to be comparable to 177Lu when employed for targeted radionuclide therapy and have potential for clinical translation and be of particular interest in tandem with 44Sc or 43Sc as a diagnostic match, enabling the realization of radiotheragnostics in future. Expand
In Vivo Labeling of Plasma Proteins for Imaging of Enhanced Vascular Permeability in the Lungs.
The investigated radioligands, 44Sc/177Lu-DOTA-PPB-01 and 44Sc-Dota- PPB-03, hold promise for the visualization of vascular leakage in a variety of pathological conditions and would be the radionuclide of choice for clinical application as it can be stably coordinated with a DOTA chelator and enables PET imaging over extended periods. Expand
The ISOLPHARM project: A New ISOL production method of high specific activity beta-emitting radionuclides as radiopharmaceutical precursors
The ISOLPHARM project explores the feasibility of exploiting an innovative technology to produce extremely high specific activity beta-emitting radionuclides as radiopharmaceutical precursors. This...