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Determination of the class and isoform selectivity of small-molecule histone deacetylase inhibitors.
TLDR
Testing a number of clinically relevant HDACis (HDAC inhibitors) against a panel of rhHDAC (recombinant human HDAC) isoforms showed that both pan- HDAC and class-I-specific inhibitor treatment resulted in increased acetylation of histones, but only pan-HDAC inhibitor treatment resulting in increased tubulin acetylations, which is in agreement with their activity towards the HDAC6 isoform.
PDGF-D, a new protease-activated growth factor
TLDR
A new member of the PDGF family, PDGF D, which also requires proteolytic activation is identified and characterized, which indicates that PDGFR-α activation may result from PDG FR-α/β heterodimerization.
CR011, a fully human monoclonal antibody-auristatin E conjugate, for the treatment of melanoma.
TLDR
These preclinical results support the continued evaluation of CR011-vcMMAE for the treatment of melanoma and help identify melanoma-associated cell surface molecules and develop as well as preclinically test immunotherapeutic reagents designed to exploit such targets.
Chromosome 3p14 homozygous deletions and sequence analysis of FRA3B.
TLDR
It is proposed that some putative targets including FRA3B may undergo loss as a consequence of genomic instability, not due to DNA mismatch repair deficiency, but may correlate in part with p53 inactivation.
Multicolor FISH mapping of YAC clones in 3p14 and identification of a YAC spanning both FRA3B and the t(3;8) associated with hereditary renal cell carcinoma.
TLDR
Multicolor fluorescence in situ hybridization analysis (FISH) on metaphase spreads and interphase nuclei is used to order 14 yeast artificial chromosomes (YACs) in 3p14 and identify YACs that closely flanked both the t(3;8) translocation breakpoint and the fragile site.
Direct cloning of DNA sequences from the common fragile site region at chromosome band 3p14.2.
TLDR
The isolation and characterization of the DNA sequences from two independent integrations into 3p14.2, a common fragile site, suggest that the structure of FRA3B differs from that of rare fragile sites.
Consistent chromosome 3p deletion and loss of heterozygosity in renal cell carcinoma.
TLDR
Findings suggest that RCCs may arise by the deletion of a "recessive cancer gene," as do retinoblastoma and Wilms tumor.
Distinct 3p21.3 deletions in lung cancer and identification of a new human semaphorin.
TLDR
It is demonstrated the presence of a distinct 3p21.3 homozygous deletion region, adjacent to the DNA mismatch repair gene, hMLH1, and identified deletions in direct tumors, which appears to represent one of the first demonstrations ofhomozygous deletions affecting 3p in direct lung tumors.
The hereditary renal cell carcinoma 3;8 translocation fuses FHIT to a patched-related gene, TRC8.
TLDR
It is shown that the 8q24.1 breakpoint region encodes a 664-aa multiple membrane spanning protein, TRC8, with similarity to the hereditary basal cell carcinoma/segment polarity gene, patched, which might function as a signaling receptor and other pathway members, to be defined, are mutation candidates in malignant diseases involving the kidney and thyroid.
Identification of a novel human fibroblast growth factor and characterization of its role in oncogenesis.
TLDR
Using a homology-based genomic DNA mining process, a human gene encoding a novel member of the FGF family is identified, that is designated FGF-20, to be a novel oncogene that may play a role in human cancer.
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