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Interaction of chlorogenic acids and quinides from coffee with human serum albumin.
- Valentina Sinisi, C. Forzato, N. Cefarin, L. Navarini, F. Berti
- Chemistry, Medicine
- Food chemistry
- 1 February 2015
Interestingly in the case of 3,4-O-dicaffeoyl-1,5-γ-quinide, it is observed the entrance of two ligand molecules in the same binding site, leading up to a first dissociation constant even in the hundred nanomolar range, which is to the authors' knowledge the highest affinity ever observed for HSA and its ligands. Expand
Effect of size and N-terminal residue characteristics on bacterial cell penetration and antibacterial activity of the proline-rich peptide Bac7.
- F. Guida, M. Benincasa, +4 authors A. Tossi
- Chemistry, Medicine
- Journal of medicinal chemistry
- 14 January 2015
The authors' studies allowed building a more detailed model for the mode-of-action of Bac7, and confirming its potential as an anti-infective agent, also suggesting it may be a vehicle for internalization of other antibiotic cargo. Expand
Sandwich ELISA assay for the quantitation of palytoxin and its analogs in natural samples.
- S. Boscolo, M. Pelin, +10 authors A. Tubaro
- Biology, Medicine
- Environmental science & technology
- 1 February 2013
An indirect sandwich ELISA for palyt toxin and 42-hydroxy-palytoxin is developed and performed well in three different matrices: observed LOQs were 11.0, 9.6, and 2.4 ng/mL for mussel extracts, algal net samples and seawater, respectively, with good accuracy and precision. Expand
Short peptides as biosensor transducers
This review deals with short peptides (up to 50 amino acids) as biomimetic active recognition elements in sensing systems, and how they are used as active elements for the detection of their own natural receptors. Expand
Highly sensitive electrochemiluminescent nanobiosensor for the detection of palytoxin.
An ultrasensitive electrochemiluminescence-based sensor is developed for the detection of palytoxin, taking advantage of the specificity provided by anti-PlTX antibodies, the good conductive properties of carbon nanotubes, and the excellent sensitivity achieved by a luminescent-based transducer. Expand
Structuring and interactions of human β‐defensins 2 and 3 with model membranes
It is proposed that both peptides interact with membranes as extended β‐sheet platforms that present amphipathic helices for insertion into the lipid bilayer. Expand
Synthesis, biological activity and modelling studies of two novel anti HIV PR inhibitors with a thiophene containing hydroxyethylamino core
An efficient method has been developed for the synthesis of a versatile intermediate bearing azido, hydroxyl and ester functions, a useful precursor for peptidomimetic compounds. The two main… Expand
Designing Short Peptides with High Affinity for Organic Molecules: A Combined Docking, Molecular Dynamics, And Monte Carlo Approach.
We present a method for designing artificial receptors capable of binding with high affinity to a chosen target organic molecule. The primary sequence of the peptide is optimized to maximize its… Expand
Chlorogenic Compounds from Coffee Beans Exert Activity against Respiratory Viruses.
3,4-O-dicaffeoyl-1,5-γ-quinide is a relevant candidate for lead optimization and further mechanistic studies, and warrants clinical development as a potential anti-respiratory syncytial virus drug. Expand
Structuring and interactions of human beta-defensins 2 and 3 with model membranes.
It is proposed that both peptides interact with membranes as extended beta-sheet platforms that present amphipathic helices for insertion into the lipid bilayer, and may modulate the efficiency of membrane insertion and selectivity for microbial or host-cell membranes. Expand