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Efficient rescue of integrated shuttle vectors from transgenic mice: a model for studying mutations in vivo.
- J. Gossen, W. D. de Leeuw, +5 authors J. Vijg
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 1 October 1989
To study gene mutations in different organs and tissues of an experimental animal, we produced transgenic mice harboring bacteriophage lambda shuttle vectors integrated in the genome in a… Expand
Kinetics of the formation and removal of cisplatin-DNA adducts in blood cells and tumor tissue of cancer patients receiving chemotherapy: comparison with in vitro adduct formation.
- A. Fichtinger-Schepman, S. D. van der Velde-Visser, H. C. van Dijk-Knijnenburg, A. V. van Oosterom, R. Baan, F. Berends
- Cancer research
- 15 December 1990
During chemotherapy with a cisplatin-containing combination of drugs, 217 blood samples from 30 cancer patients were analyzed for the presence of the main cisplatin-DNA adduct cis-Pt(NH3)2d(pGpG)… Expand
DNA damage metabolism and aging.
As a result of permanent exposure to low levels of various endogenous and exogenous genotoxic agents, large numbers of lesions are continuously induced in the DNA of cells of living organisms. Such… Expand
Formation of DNA adducts by the anticancer drug carboplatin: different nucleotide sequence preferences in vitro and in cells.
- F. A. Blommaert, H. C. van Dijk-Knijnenburg, +4 authors A. Fichtinger-Schepman
- 4 July 1995
We have studied the formation of adducts upon carboplatin treatment of isolated DNA and in cells. The major adduct formed in vitro, determined with atomic absorption spectroscopy and enzyme-linked… Expand
Formation and repair of DNA interstrand cross-links in relation to cytotoxicity and unscheduled DNA synthesis induced in control and mutant human cells treated with cis-diamminedichloroplatinum(II).
A comparative study was performed with a variety of human cell lines on the effects of treatments with cis-diamminedichloroplatinum(II) (cisplatin) on cell survival and the induction of unscheduled… Expand
The mutagenicity of isoniazid in Salmonella and its effects on DNA repair and synthesis in human fibroblasts.
A commercial sample of the tuberculostatic drug isoniazid (INH) was found to have a weak mutagenic activity towards Salmonella typhimurium strains TA100 and TA1535. The addition of a rat or mouse… Expand
Cisplatin- and carboplatin-DNA adducts: is PT-AG the cytotoxic lesion?
- A. Fichtinger-Schepman, H. C. van Dijk-Knijnenburg, S. D. van der Velde-Visser, F. Berends, R. Baan
- Biology, Medicine
- 1 October 1995
In order to determine the nature of the cytotoxic lesion(s) formed by the antitumour drugs cisplatin and carboplatin, a comparative study was made of bifunctional DNA-adduct formation by these drugs.… Expand
Gonadal status and outcome of bariatric surgery in obese men
Obesity‐related hypogonadotrophic hypogonadism (OrHH) occurs in over 40% of morbidly obese men. Obesity‐related hypogonadotrophic hypogonadism may reduce the beneficial effects of bariatric surgery.
The validity of the autoradiographic method for detecting DNA repair synthesis in rat hepatocytes in primary culture.
Abstract The autoradiographic detection of unscheduled DNA synthesis (UDS) in primary cultures of rat hepatocytes (HPC) was used to measure excision repair of DNA lesions induced by genotoxic agents.… Expand