• Publications
  • Influence
Direct Interaction of the Rat unc-13 Homologue Munc13-1 with the N Terminus of Syntaxin*
unc-13 mutants in Caenorhabditis elegans are characterized by a severe deficit in neurotransmitter release. Their phenotype is similar to that of the C. elegans unc-18 mutation, which is thought toExpand
Modification of cognitive performance in schizophrenia by complexin 2 gene polymorphisms.
CONTEXT Schizophrenia is the collective term for a heterogeneous group of mental disorders with a still obscure biological basis. In particular, the specific contribution of risk or candidate geneExpand
A CAG repeat polymorphism of KCNN3 predicts SK3 channel function and cognitive performance in schizophrenia
KCNN3, encoding the small conductance calcium‐activated potassium channel SK3, harbours a polymorphic CAG repeat in the amino‐terminal coding region with yet unproven function. Hypothesizing thatExpand
Oligonucleotide duplexes containing 2'-amino-2'-deoxycytidines: thermal stability and chemical reactivity [published erratum appears in Nucleic Acids Res 1994 Feb 25;22(4): 701]
Thermal stabilities of oligonucleotides containing 2'-amino-2'-deoxycytidines were determined and compared to those of the unmodified oligonucotides. Expand
A new approach to the synthesis of a protected 2-aminopurine derivative and its incorporation into oligodeoxynucleotides containing the Eco RI and Bam HI recognition sites.
A protected 2-aminopurine nucleoside suitable for incorporation into oligodeoxynucleotides using phosphite triester chemical synthesis procedures has been prepared via oxidation of a purine hydrazinoExpand
Elucidation of Basic Mechanistic and Kinetic Properties of Influenza Endonuclease Using Chemically Synthesized RNAs (*)
Influenza virus utilizes a unique mechanism for initiating the transcription of viral mRNA. The viral transcriptase ribonucleoprotein complex hydrolyzes host cell transcripts containing the cap 1Expand
Optimizing Nervous System-Specific Gene Targeting with Cre Driver Lines: Prevalence of Germline Recombination and Influencing Factors
The Cre-loxP system is invaluable for spatial and temporal control of gene knockout, knockin, and reporter expression in the mouse nervous system. However, we report varying probabilities ofExpand
Effects of functional group changes in the EcoRI recognition site on the cleavage reaction catalyzed by the endonuclease.
Oligodeoxynucleotides have been prepared that contain changes in the functional group pattern present in the EcoRI recognition site. These changes involve "functional group deletions", "functionalExpand
A single methyl group prevents the mischarging of a tRNA
Arginyl-tRNA synthase will erroneously add Arg to tRNAAsp following a single nucleotide mutation of tRNAAsp.