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Circuit-based framework for understanding neurotransmitter and risk gene interactions in schizophrenia
Many risk genes interact synergistically to produce schizophrenia and many neurotransmitter interactions have been implicated. We have developed a circuit-based framework for understanding gene andExpand
GABAergic Interneurons: Implications for Understanding Schizophrenia and Bipolar Disorder
A core component to corticolimbic circuitry is the GABAergic interneuron. Neuroanatomic studies conducted over the past century have demonstrated several subtypes of interneuron defined byExpand
Fear Conditioning Occludes LTP-Induced Presynaptic Enhancement of Synaptic Transmission in the Cortical Pathway to the Lateral Amygdala
Auditory information critical for fear conditioning, a model of emotional learning, is conveyed to the lateral nucleus of the amygdala via two routes: directly from the medial geniculate nucleus andExpand
Molecular evidence for mitochondrial dysfunction in bipolar disorder.
BACKGROUND The disease mechanism of bipolar disorder remains unknown. Recent studies have provided evidence for abnormal gene expression in bipolar disorder. OBJECTIVE To determine the expressionExpand
Myelination of a key relay zone in the hippocampal formation occurs in the human brain during childhood, adolescence, and adulthood.
BACKGROUND A previous study demonstrated that myelination of the superior medullary lamina along the surface of the parahippocampal gyrus is occurring in human brain during adolescence. To furtherExpand
Emerging principles of altered neural circuitry in schizophrenia
  • F. Benes
  • Medicine, Psychology
  • Brain Research Reviews
  • 1 March 2000
This paper presents an overview of recent microscopic studies that have sought to define how limbic circuitry may be altered in postmortem schizophrenic brain. The discussion is organized aroundExpand
Amygdalo‐cortical sprouting continues into early adulthood: Implications for the development of normal and abnormal function during adolescence
Adolescence is a critical stage for the development of emotional maturity and diverse forms of psychopathology. The posterior basolateral nucleus of the amygdala is known to mediate fear and anxietyExpand
Deficits in small interneurons in prefrontal and cingulate cortices of schizophrenic and schizoaffective patients.
A recent report suggested that neurons in the prefrontal, anterior cingulate, and primary motor cortex of the brains of schizophrenic subjects may be less dense than those in the brains ofExpand
Analysis of Variance for Replicated Spatial Point Patterns in Clinical Neuroanatomy
Abstract Our application concerns the analysis of the spatial distributions of pyramidal neurons in the cingulate cortex of human subjects in three diagnostic groupings. Our purpose is to develop andExpand
Myelination of cortical-hippocampal relays during late adolescence.
  • F. Benes
  • Psychology, Medicine
  • Schizophrenia bulletin
  • 1989
The normal developmental series of brains in the Yakovlev Collection has been examined to explore the possibility that various brain regions implicated in schizophrenia may show changes inExpand