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CX3CR1-dependent subretinal microglia cell accumulation is associated with cardinal features of age-related macular degeneration.
TLDR
Results show that CX3CR1-dependent accumulation of subretinal MCs evokes cardinal features of AMD and reveal what the authors believe to be a novel pathogenic process with important implications for the development of new therapies for AMD.
Central serous chorioretinopathy: Recent findings and new physiopathology hypothesis
TLDR
The aim of this review is to recapitulate the clinical understanding of CSCR, with an emphasis on the most recent findings on epidemiology, risk factors, clinical and imaging diagnosis, and treatments options, and the novel mineralocorticoid pathway hypothesis.
CCR2+ monocytes infiltrate atrophic lesions in age-related macular disease and mediate photoreceptor degeneration in experimental subretinal inflammation in Cx3cr1 deficient mice
TLDR
It is shown that atrophic AMD is associated with increased intraocular CCL2 levels and subretinal CCR2+ inflammatory monocyte infiltration in patients and CCL/CCR2 inhibition might represent a powerful tool for controlling inflammation and neurodegeneration in AMD.
Mineralocorticoid receptor is involved in rat and human ocular chorioretinopathy.
TLDR
The results identify MR signaling as a pathway controlling choroidal vascular bed relaxation and provide a pathogenic link with human CSCR, which suggests that blockade of MR could be used therapeutically to reverse choroid vasculopathy.
Intraocular implants for extended drug delivery: therapeutic applications.
TLDR
An overview of ocular implants with therapeutic application potentials is provided andMiniaturization of the implants allowing for their direct injection without the need for a complicated surgery is a necessary development avenue.
Ocular drug delivery targeting the retina and retinal pigment epithelium using polylactide nanoparticles.
TLDR
The presence of the NPs within the RPE cells 4 months after a single injection shows that a steady and continuous delivery of drugs can be achieved, and supports the idea that specific targeting of these tissues is feasible.
Mechanisms of macular edema: Beyond the surface
TLDR
This comprehensive review on the current understanding of macular edema and its mechanisms opens perspectives to identify new preventive and therapeutic strategies for this sight-threatening condition.
Light-emitting diodes (LED) for domestic lighting: Any risks for the eye?
TLDR
A comprehensive analysis of the potential risks of white LEDs is given, taking into account pre-clinical knowledge as well as epidemiologic studies and reports the French Agency's recommendations to avoid potential retinal hazards.
Cyclosporine A delivery to the eye: a pharmaceutical challenge.
TLDR
There is still room for improvement in CsA ocular application, as none of these formulations is ideal, and the use of colloidal carriers, microspheres, implants and liposomes have been developed to be directly administered subconjunctivally or intravitreally in order to enhance C'sA concentration in the vitreous.
Ranibizumab versus Bevacizumab for Neovascular Age-related Macular Degeneration: Results from the GEFAL Noninferiority Randomized Trial.
TLDR
Bvacizumab was noninferior to ranibizumAB for visual acuity at 1 year with similar safety profiles, and Ranibizuab tended to have a better anatomic outcome.
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