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PRT1 of Arabidopsis thaliana encodes a component of the plant N-end rule pathway.
TLDR
Mutants in the PRT1 gene of Arabidopsis thaliana are impaired in the degradation of a normally short-lived intracellular protein that contains a destabilizing N-terminal residue, consistent with the proposed role ofPRT1 in the plant N-end rule pathway. Expand
Perturbation of the ubiquitin system causes leaf curling, vascular tissue alterations and necrotic lesions in a higher plant.
TLDR
P perturbations of the ubiquitin system can induce a programmed necrotic response in plants, and the role of this proteolytic pathway in the life cycle of plants is assessed. Expand
Expression of the 180-Kd Ribosome Receptor Induces Membrane Proliferation and Increased Secretory Activity in Yeast
TLDR
It is concluded that p180 expression triggers a cascade of events leading to an increase in secretory potential akin to the terminal differentiation of mammalian secretory cells and tissues. Expand
Use of a reporter transgene to generate arabidopsis mutants in ubiquitin-dependent protein degradation.
Ubiquitin-dependent proteolysis is a major proteolytic pathway in the cytoplasm and nucleus of eukaryotic cells. We introduced a gene encoding a substrate for this pathway into the genome ofExpand
A three-hybrid approach to scanning the proteome for targets of small molecule kinase inhibitors.
TLDR
The Y3H system described here may prove generally useful in the discovery of candidate drug targets in scanning the proteome for targets of kinase inhibitors. Expand
Purification of tobacco nuclear proteins binding to a CACGTG motif of the chalcone synthase promoter by DNA affinity chromatography.
TLDR
Nuclear factor from Nicotiana tabacum, termed CG-1, that specifically recognize(s) this transcriptional element in the ultraviolet-light-regulated Antirrhinum majus chalcone synthase promoter is identified. Expand
Altered response to viral infection by tobacco plants perturbed in ubiquitin system.
TLDR
Tobacco plants can be perturbed in their Ubiquitin system by expression of a ubiquitin variant with a lys to arg change at position 48, which leads to changes in the response of both resistant and susceptible tobacco varieties. Expand
A proteome-wide CDK/CRK-specific kinase inhibitor promotes tumor cell death in the absence of cell cycle progression.
TLDR
A small-molecule kinase inhibitor is described, which, besides inhibiting tumor cell cycle progression, exhibits potent cytotoxic activity toward noncycling tumor cells, but not nontransformed quiescent fibroblasts. Expand
Immuno-electron microscopic quantification of the fucoxanthin chlorophyll a/c binding polypeptides Fcp2, Fcp4, and Fcp6 of Cyclotella cryptica grown under low- and high-light intensities.
  • F. Becker, E. Rhiel
  • Biology, Medicine
  • International microbiology : the official journal…
  • 1 March 2006
TLDR
Molecular data derived from phylogenetic analyses of the sequences of genes encoding fucoxanthin chlorophyll a/c binding polypeptides (fcp genes) and from measurements of steady-state fcp mRNA concentrations show that Fcp2 and Fcp6 accumulate under low- and high-light intensity, respectively, whereas Fcp4 seems to be constitutively synthesized. Expand
Homogeneous time-resolved G protein-coupled receptor-ligand binding assay based on fluorescence cross-correlation spectroscopy.
TLDR
This work demonstrates the suitability of the homogeneous and time-resolved FCCS assay format for a robust, high-throughput determination of receptor-ligand binding affinities and kinetic rate constants for various therapeutically relevant GPCRs. Expand
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