• Publications
  • Influence
Board-invited review: intrauterine growth retardation: implications for the animal sciences.
TLDR
There is growing evidence that maternal nutritional status can alter the epigenetic state (stable alterations of gene expression through DNA methylation and histone modifications) of the fetal genome, which may provide a molecular mechanism for the role of maternal nutrition on fetal programming and genomic imprinting. Expand
Arginine metabolism and nutrition in growth, health and disease
TLDR
The results of both experimental and clinical studies indicate that Arg is a nutritionally essential amino acid (AA) for spermatogenesis, embryonic survival, fetal and neonatal growth, as well as maintenance of vascular tone and hemodynamics and novel and effective therapies for obesity, diabetes, and the metabolic syndrome. Expand
Developmental Biology of Uterine Glands1
TLDR
That disruption of uterine development during critical organizational periods can alter the functional capacity and embryotrophic potential of the adult uterus reinforces the importance of understanding the developmental biology of uterusine glands. Expand
Implantation mechanisms: insights from the sheep.
TLDR
Understanding of the cellular and molecular signals that regulate uterine receptivity and implantation can be used to diagnose and identify causes of recurrent pregnancy loss and to improve pregnancy outcome in domestic animals and humans. Expand
Maternal nutrition and fetal development.
TLDR
There is growing evidence that maternal nutritional status can alter the epigenetic state (stable alterations of gene expression through DNA methylation and histone modifications) of the fetal genome, which may provide a molecular mechanism for the impact of maternal nutrition on both fetal programming and genomic imprinting. Expand
Conceptus signals for establishment and maintenance of pregnancy
  • T. Spencer, F. Bazer
  • Biology, Medicine
  • Reproductive biology and endocrinology : RB&E
  • 5 July 2004
TLDR
Subsequently, sequential, overlapping actions of progesterone, IFN tau, placental lactogen (PL) and growth hormone (GH) comprise a hormonal servomechanism that regulates endometrial gland morphogenesis and terminal differentiated function to maintain pregnancy in sheep. Expand
Establishment of pregnancy in the pig: II. Cellular remodeling of the porcine blastocyst during elongation on day 12 of pregnancy.
TLDR
The morphology of pig blastocysts changes dramatically just preceding initial attachment of the trophoblast to the uterine epitheliuin, and possible mechanism(s) involved with changes in blastocyst morphology are investigated. Expand
Dietary L-arginine supplementation enhances the reproductive performance of gilts.
TLDR
Testing the hypothesis that dietary l-arginine supplementation may improve reproductive performance of pregnant gilts provided the first evidence for a marked increase of live-born piglets by 2 per litter through nutritional intervention in gilts. Expand
Triennial Growth Symposium: important roles for L-glutamine in swine nutrition and production.
TLDR
Dietary supplementation with 1% Gln maintains gut health and prevents intestinal dysfunction in low-birth-weight or early-weaned piglets while increasing their growth performance and survival, and enhances milk production by lactating sows. Expand
Comparative aspects of implantation.
TLDR
There is compelling evidence that uterine receptivity to implantation involves temporal and cell-specific expression of interferon (IFN)-stimulated genes that have many roles including nutrient transport, cellular remodeling, angiogenesis and relaxation of vascular tissues, cell proliferation and migration, establishment of an antiviral state, and protection of conceptus tissues from challenges by the maternal immune cells. Expand
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