• Publications
  • Influence
Epileptic fast activity can be explained by a model of impaired GABAergic dendritic inhibition
Results show that strikingly realistic activity is produced by the model when compared to real EEG signals recorded with intracerebral electrodes, and show that the transition from interictal to fast ictal activity is explained by the impairment of dendritic inhibition. Expand
Relevance of nonlinear lumped-parameter models in the analysis of depth-EEG epileptic signals
This study demonstrates that a neurophysiologically relevant model can be extended to generate spontaneous EEG signals from multiple coupled neural populations and shows that, through the model, real SEEG signals can be interpreted with the aid of signal processing methods. Expand
Decreased basal fMRI functional connectivity in epileptogenic networks and contralateral compensatory mechanisms
A better understanding of interstructure relationship sustaining drug‐resistant epileptogenic networks is crucial for surgical perspective and to better understand the consequences of epilepticExpand
Small-world networks and epilepsy: Graph theoretical analysis of intracerebrally recorded mesial temporal lobe seizures
During seizures, the neuronal network moves in the direction of a more ordered configuration compared to the more randomly organized interictal network, even after correcting for changes in synchronization strength. Expand
Interictal to Ictal Transition in Human Temporal Lobe Epilepsy: Insights From a Computational Model of Intracerebral EEG
Electrophysiologic patterns typically observed during the transition from interictal to ictal activity in human mesial temporal lobe epilepsy are related to mechanisms (at a neuronal population level) involved in seizure generation through a computational model of EEG activity. Expand
Epileptogenicity of brain structures in human temporal lobe epilepsy: a quantified study from intracerebral EEG.
A statistically significant correlation was found between the duration of epilepsy and the number of structures disclosing high epileptogenicity suggesting that MTLE is a gradually evolving process in which the epileptogensicity of the temporal lobe tends to increase with time. Expand
The role of corticothalamic coupling in human temporal lobe epilepsy.
It is demonstrated that the thalamus and remote cortical structures synchronize their activity during TLE seizures and suggested that the extension of the epileptogenic network to theThalamus is a potential important factor determining surgical prognosis. Expand
International consensus classification of hippocampal sclerosis in temporal lobe epilepsy: A Task Force report from the ILAE Commission on Diagnostic Methods
The proposed international consensus classification of hippocampal neuronal cell loss will aid in the characterization of specific clinicopathologic syndromes, and explore variability in imaging and electrophysiology findings, and in postsurgical seizure control. Expand
Gamma Knife Surgery in Mesial Temporal Lobe Epilepsy: A Prospective Multicenter Study
Summary:  Purpose: This article is the first prospective documentation of the efficacy and safety of gamma knife surgery (GKS) in the treatment of drug‐resistant epilepsies of mesial temporal lobeExpand
Enhanced EEG functional connectivity in mesial temporal lobe epilepsy
This study shows that, during the interictal state, the EZ in MTLE is characterized by a decrease of oscillations in the theta sub-band and by a general increase of signal interdependencies, which suggests that the EEZ is characterize by network of neuronal assemblies with a reinforced functional connectivity. Expand