F. Barré-Sinoussi

Publications263
h-index59
Citations19,310
Highly Influential Citations591
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Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS).
TLDR
From these studies it is concluded that this virus as well as the previous HTLV isolates belong to a general family of T-lymphotropic retroviruses that are horizontally transmitted in humans and may be involved in several pathological syndromes, including AIDS. Expand
Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS). 1983.
TLDR
It is concluded that this virus as the previous HTVL isolate belong to a general family of T-lymphotropic retroviruses that are horizontally transmitted in human and may be involved in several pathological syndromes, including AIDS. Expand
Identification of a new human immunodeficiency virus type 1 distinct from group M and group O
TLDR
YBF30 is as distinct from SIVcpz-gab as it is from HIV-1 group M and can thus be considered as the prototype strain of a new human immunodeficiency virus group. Expand
env Sequences of Simian Immunodeficiency Viruses from Chimpanzees in Cameroon Are Strongly Related to Those of Human Immunodeficiency Virus Group N from the Same Geographic Area
TLDR
SIVcpz from chimpanzees born in the wild in Cameroon are strongly related inenv to HIV-1 N from Cameroon, demonstrating the geographic coincidence of these human and simian viruses and providing a further strong argument in favor of the origin of HIV- 1 being in chimpanzees. Expand
Cis elements and trans-acting factors involved in the RNA dimerization of the human immunodeficiency virus HIV-1.
TLDR
It is reported that HIV-1 RNA forms dimeric molecules and that viral nucleocapsid protein NCp15 greatly activates dimerization, and cross-linking analysis of the interactions between NC and HIV- 1 RNA shows that NC protein molecules are tightly bound to the genomic RNA dimer. Expand
Nonpathogenic SIV infection of African green monkeys induces a strong but rapidly controlled type I IFN response.
TLDR
SIV infection triggered a rapid and strong IFN-alpha response in vivo in both AGMs and RMs, with this response being efficiently controlled only in AGMs, possibly as a result of active regulatory mechanisms. Expand
Wild Mandrillus sphinx Are Carriers of Two Types of Lentivirus
TLDR
E Epidemiological surveys of human immunodeficiency virus revealed a case in Cameroon of a human infected by a virus serologically related to SIVmnd, raising the possibility that mandrills represent a viral reservoir for humans similar to sooty mangabeys in Western Africa and chimpanzees in Central Africa. Expand
Serological and virological characterization of HIV‐1 group O infection in Cameroon
TLDR
The wide distribution of group O infection in all Cameroonian provinces underlines the importance of further characterizing the epidemic spread and diffusion of this group. Expand
Antiinflammatory profiles during primary SIV infection in African green monkeys are associated with protection against AIDS.
TLDR
The data show that SIVagm infection is associated with an immediate antiinflammatory environment and suggest that TGF-beta may participate in the generation of Tregs, which may prevent an aberrant chronic T cell hyperactivation. Expand
Programmed cell death and AIDS: significance of T-cell apoptosis in pathogenic and nonpathogenic primate lentiviral infections.
We have proposed that inappropriate induction of programmed cell death (PCD) or apoptosis, a physiological cell-suicide process, may play a role in the pathogenesis of AIDS. This model has been… Expand
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