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Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration
Summary Cerebral small vessel disease (SVD) is a common accompaniment of ageing. Features seen on neuroimaging include recent small subcortical infarcts, lacunes, white matter hyperintensities,… Expand
Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis.
BACKGROUND Fingolimod (FTY720), a sphingosine-1-phosphate-receptor modulator that prevents lymphocyte egress from lymph nodes, showed clinical efficacy and improvement on imaging in a phase 2 study… Expand
Comparison of MRI criteria at first presentation to predict conversion to clinically definite multiple sclerosis.
We compared MRI criteria used to predict conversion of suspected multiple sclerosis to clinically definite multiple sclerosis. Seventy-four patients with clinically isolated neurological symptoms… Expand
Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria
- A. Thompson, B. Banwell, F. Barkhof, W. Carroll, J. Cohen
- The Lancet Neurology
- 21 December 2017
The 2010 McDonald criteria for the diagnosis of multiple sclerosis are widely used in research and clinical practice. Scientific advances in the past 7 years suggest that they might no longer provide… Expand
Atrophy of medial temporal lobes on MRI in "probable" Alzheimer's disease and normal ageing: diagnostic value and neuropsychological correlates.
- P. Scheltens, D. Leys, +7 authors J. Valk
- Journal of neurology, neurosurgery, and…
- 1 October 1992
Magnetic resonance imaging (MRI) has shown a great reduction in medial temporal lobe and hippocampal volume of patients with Alzheimer's disease as compared to controls. Quantitative volumetric… Expand
Altered resting state networks in mild cognitive impairment and mild Alzheimer's disease: An fMRI study
- S. Rombouts, F. Barkhof, R. Goekoop, C. Stam, P. Scheltens
- Psychology, Medicine
- Human brain mapping
- 1 December 2005
Activity and reactivity of the default mode network in the brain was studied using functional magnetic resonance imaging (fMRI) in 28 nondemented individuals with mild cognitive impairment (MCI), 18… Expand
Effect of early interferon treatment on conversion to definite multiple sclerosis: a randomised study
- G. Comi, the Early Treatment of Multiple Sclerosis Study Group, M. Filippi, F. Barkhof, O. Hommes
- The Lancet
- 19 May 2001
BACKGROUND Interferon beta reduces activity in multiple sclerosis as measured clinically and by magnetic resonance imaging (MRI). We assessed the effect of interferon beta-1a on the occurrence of… Expand
Clinically isolated syndromes suggestive of multiple sclerosis, part I: natural history, pathogenesis, diagnosis, and prognosis
In 85% of young adults with multiple sclerosis (MS), onset is a subacute clinically isolated syndrome (CIS) of the optic nerves, brainstem, or spinal cord. Methods of assessing the prognosis for… Expand
Cortical lesions in multiple sclerosis.
- D. Kidd, F. Barkhof, R. McConnell, P. Algra, I. Allen, T. Revesz
- Brain : a journal of neurology
Although previous studies have shown that the lesions of multiple sclerosis may involve the cerebral cortex, there is little published research on the prevalence and distribution of such lesions.… Expand
Loss of ‘Small-World’ Networks in Alzheimer's Disease: Graph Analysis of fMRI Resting-State Functional Connectivity
Background Local network connectivity disruptions in Alzheimer's disease patients have been found using graph analysis in BOLD fMRI. Other studies using MEG and cortical thickness measures, however,… Expand