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Consistent resting-state networks across healthy subjects
- J. Damoiseaux, S. Rombouts, C. Beckmann
- Psychology, BiologyProceedings of the National Academy of Sciences
- 12 September 2006
Findings show that the baseline activity of the brain is consistent across subjects exhibiting significant temporal dynamics, with percentage BOLD signal change comparable with the signal changes found in task-related experiments.
Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration
Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria
Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis.
- Jeffrey A. Cohen, F. Barkhof, L. Kappos
- Medicine, PsychologyThe New England journal of medicine
- 5 March 2010
This trial showed the superior efficacy of oral fingolimod with respect to relapse rates and MRI outcomes in patients with multiple sclerosis, as compared with intramuscular interferon beta-1a.
Defining the clinical course of multiple sclerosis
Refined descriptors that include consideration of disease activity (based on clinical relapse rate and imaging findings) and disease progression are proposed and strategies for future research to better define phenotypes are outlined.
Reduced resting-state brain activity in the "default network" in normal aging.
This work examined the functional properties of brain networks based on spontaneous fluctuations within brain systems using functional magnetic resonance imaging to hypothesized that functional connectivity of intrinsic brain activity in the "default-mode" network (DMN) is affected by normal aging and that this relates to cognitive function.
Comparison of MRI criteria at first presentation to predict conversion to clinically definite multiple sclerosis.
It is concluded that a four-parameter dichotomized MRI model including gadolinium-enhancement, juxtacortical, infratentorial and periventricular lesions best predicts conversion to clinically definite multiple sclerosis.
Atrophy of medial temporal lobes on MRI in "probable" Alzheimer's disease and normal ageing: diagnostic value and neuropsychological correlates.
- P. Scheltens, D. Leys, J. Valk
- Psychology, MedicineJournal of neurology, neurosurgery, and…
- 1 October 1992
This study shows that MTA shown on MRI strongly supports the clinical diagnosis of Alzheimer's disease, is related to memory function, and seems to occur earlier in the disease process than does generalised brain atrophy.
A New Rating Scale for Age-Related White Matter Changes Applicable to MRI and CT
A new ARWMC scale applicable to both CT and MRI that has almost equal sensitivity, except for certain regions is presented, including frontal area and basal ganglia and infratentorial areas.
Altered resting state networks in mild cognitive impairment and mild Alzheimer's disease: An fMRI study
- S. Rombouts, F. Barkhof, R. Goekoop, C. Stam, P. Scheltens
- Biology, PsychologyHuman brain mapping
- 1 December 2005
Altered activity in the default mode network may act as an early marker for AD pathology, suggesting that MCI is a transitional state between healthy aging and dementia and with the proposed early changes in MCI in the posterior cingulate cortex and precuneus.