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Structure–effect relation of C18 long-chain fatty acids in the reduction of body weight in rats
TLDR
Both cis-configured monounsaturated C18 fatty acids (oleic acid and 2-OHOA) reduce body weight, but the introduction of a hydroxyl group in position 2 drastically increases loss of adipose tissue mass. Expand
Kinetics and thermodynamics of triple-helix formation: effects of ionic strength and mismatches.
TLDR
Thermodynamic and kinetic parameters for the triplex-forming reactions between a homopurine-homopyrimidine 22-base-pair duplex and the four 22-dN third strands were determined from thermal denaturation and renaturation UV absorbance profiles, consistent with the prediction of two-state association and dissociation. Expand
Plant pentacyclic triterpenic acids as modulators of lipid membrane physical properties.
TLDR
Experimental evidence that TTPs altered the structural properties of 1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine (DPPC) and DPPC-Cholesterol (Cho) rich membranes, being located into the polar-hydrophobic interphase is provided, strengthening the relevance of TTP interactions with cell membranes as a molecular mechanism underlying their broad spectrum of biological effects. Expand
Thermodynamic characterization of the multivalent binding of chartreusin to DNA.
TLDR
A detailed thermodynamic profile is obtained for the interaction of this multivalent drug, which makes possible a dissection of DeltaG(obs) into the component free energy terms. Expand
Membrane structure modulation, protein kinase C alpha activation, and anticancer activity of minerval.
TLDR
The present results support the potential use of Minerval and related compounds in the treatment of tumor pathologies and inhibit the growth of cancer cells and exerted antitumor effects in animal models of cancer without apparent histological toxicity. Expand
Polymorphic curvature of satellite DNA in three subspecies of the beetle Pimelia sparsa.
TLDR
The curvature of the monomeric repeats of satellite DNAs from three subspecies of the beetle Pimelia sparsa has been analysed and the differences in sequence and the high similarity conserved in the (A+T)-rich regions are correlated with the changes in the patterns of curvature. Expand
Purification and characterization of ferritin from alfalfa seeds.
TLDR
Immunochemical analysis using polyclonal antibodies raised against pea-seed ferritin has confirmed, in agreement with previous reports, that plant proteins share common epitopes. Expand
Effects of oleic acid and its congeners, elaidic and stearic acids, on the structural properties of phosphatidylethanolamine membranes Published, JLR Papers in Press, December 16, 2002. DOI
TLDR
X-ray diffraction of PE-FA systems demonstrated that oleic acid (OA) produced important concentration-dependent alterations of the lipid membrane structure: it induced reductions of up to 20–23°C in the lamellar-to-hexagonal transition temperature of 1-palmitoyl-2-oleoyl PE and dielaidoylPE and regulated the dimensions of the hexagonal lattice. Expand
Effects of unsaturated fatty acids and triacylglycerols on phosphatidylethanolamine membrane structure Published, JLR Papers in Press, June 16, 2003. DOI 10.1194/jlr.M300092-JLR200
TLDR
It is proposed that TGs could act as lateral spacers between polar DEPE groups, providing an increase in the effective surface area per lipid molecule that would account for the structural parameters of the HII phase. Expand
Entropically-driven binding of mithramycin in the minor groove of C/G-rich DNA sequences
TLDR
The thermodynamic analysis of binding data at 25°C shows that the binding of MTA and MSK to DNA is entropically driven, dominated by the hydrophobic transfer of the antibiotics from solution to the DNA-binding site. Expand
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