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- Publications
- Influence
Altered palmitoylation and neuropathological deficits in mice lacking HIP14.
- R. Singaraja, K. Huang, +15 authors M. Hayden
- Biology, Medicine
- Human molecular genetics
- 15 October 2011
Huntingtin interacting protein 14 (HIP14, ZDHHC17) is a huntingtin (HTT) interacting protein with palmitoyl transferase activity. In order to interrogate the function of Hip14, we generated mice with… Expand
Wild-type HTT modulates the enzymatic activity of the neuronal palmitoyl transferase HIP14.
- K. Huang, S. Sanders, +9 authors M. Hayden
- Biology, Medicine
- Human molecular genetics
- 1 September 2011
Huntington disease (HD) is caused by polyglutamine expansion in the huntingtin (HTT) protein. Huntingtin-interacting protein 14 (HIP14), one of 23 DHHC domain-containing palmitoyl acyl transferases… Expand
Human Sco1 and Sco2 Function as Copper-binding Proteins*
- Y. Horng, S. C. Leary, +4 authors D. Winge
- Biology, Medicine
- Journal of Biological Chemistry
- 7 October 2005
The function of human Sco1 and Sco2 is shown to be dependent on copper ion binding. Expression of soluble domains of human Sco1 and Sco2 either in bacteria or the yeast cytoplasm resulted in the… Expand
Putting proteins in their place: Palmitoylation in Huntington disease and other neuropsychiatric diseases
- F. B. Young, S. Butland, S. Sanders, L. Sutton, M. Hayden
- Biology, Medicine
- Progress in Neurobiology
- 1 May 2012
Post-translational modification of proteins by the lipid palmitate is critical for protein localization and function. Palmitoylation is regulated by the opposing enzymes palmitoyl acyltransferases… Expand
Hip14l-deficient mice develop neuropathological and behavioural features of Huntington disease.
- L. Sutton, S. Sanders, +10 authors M. Hayden
- Biology, Medicine
- Human molecular genetics
- 1 February 2013
Palmitoylation, the dynamic post-translational addition of the lipid, palmitate, to proteins by Asp-His-His-Cys-containing palmitoyl acyltransferase (PAT) enzymes, modulates protein function and… Expand
Memory and synaptic deficits in Hip14/DHHC17 knockout mice
- A. Milnerwood, Matthew P. Parsons, +6 authors L. Raymond
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 25 November 2013
Significance Palmitoylation can influence the subcellular localization of various synaptic proteins; this process is therefore increasingly recognized as an important regulator of basal synaptic… Expand
Erratum: Human Sco1 and Sco2 function as copper-binding proteins (Journal Of Biological Chemistry (2005) 280 (34113-34122))
- Y. Horng, S. C. Leary, +4 authors D. Winge
- Chemistry
- 9 December 2005
- 4
- 1
Low Levels of Human HIP14 Are Sufficient to Rescue Neuropathological, Behavioural, and Enzymatic Defects Due to Loss of Murine HIP14 in Hip14−/− Mice
- F. B. Young, S. Franciosi, +9 authors M. Hayden
- Biology, Medicine
- PloS one
- 23 May 2012
Huntingtin Interacting Protein 14 (HIP14) is a palmitoyl acyl transferase (PAT) that was first identified due to altered interaction with mutant huntingtin, the protein responsible for Huntington… Expand
A life without pain? Hedonists take note
- F. B. Young
- Medicine, Biology
- Clinical genetics
- 7 December 2007
An SCN9A channelopathy causes congenital inability to experience pain
Cox et al. (2006)
Nature 444: 894–898
When adaptive processes go awry: gain‐of‐function in SCN9A
- F. B. Young
- Medicine, Biology
- Clinical genetics
- 7 December 2007
SCN9A mutations in paroxysmal extreme pain disorder: allelic variants underlie distinct channel defects and phenotypes
Fertleman et al. (2006)
Neuron 52: 767–774