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A Dual Program for Translation Regulation in Cellular Proliferation and Differentiation
TLDR
The existence of two distinct translation programs that operate during proliferation and differentiation are described, suggesting the existence of transcriptional programs coordinating tRNA supply and demand. Expand
Agonist-induced Conformational Changes at the Cytoplasmic Side of Transmembrane Segment 6 in the β2 Adrenergic Receptor Mapped by Site-selective Fluorescent Labeling*
TLDR
The data suggest that activation of G protein-coupled receptors, which are activated by “diffusible” ligands, involves a structural rearrangement corresponding to the cytoplasmic part of transmembrane segment (TM) 6. Expand
Structural basis for activation of G-protein-coupled receptors.
TLDR
Using the beta2-adrenergic receptor as a model system, evidence is obtained for an evolutionary conserved activation mechanism where disruption of intramolecular interactions between TM3 and TM6 leads to a major conformational change of TM6 relative to the rest of the receptor. Expand
Genome-wide profiling identifies a DNA methylation signature that associates with TET2 mutations in diffuse large B-cell lymphoma
TLDR
The data suggest that TET2 mutations may cause aberrant methylation mainly of genes involved in hematopoietic development, which are silenced but poised for activation in human embryonic stem cells. Expand
Hypermethylation of DAPK1 is an independent prognostic factor predicting survival in diffuse large B-cell lymphoma
TLDR
Methylation of the death associated protein kinase (DAPK or DAPK1) gene and TP53 mutations are likely to have prognostic value in DLBCL and it is found that D APK1 promoter methylation was associated with shorter overall survival and disease-specific survival. Expand
Frequent NFKBIE deletions are associated with poor outcome in primary mediastinal B-cell lymphoma.
TLDR
NFKBIE aberrations are identified as a common genetic event across B-cell malignancies and NFKBIe deletions are highlighted as a novel poor-prognostic marker in PMBL. Expand
Epigenetic changes in cancer as potential targets for prophylaxis and maintenance therapy.
TLDR
The prospect that epigenetic alterations may play an essential role in renewing and maintaining the malignant clone has opened up new perspectives for the use of epigenetic therapy in cancer prevention and maintenance. Expand
TP53 hotspot mutations are predictive of survival in primary central nervous system lymphoma patients treated with combination chemotherapy
TLDR
This study suggests that disruption of the p53-pathway by MUT-TP53in hotspot/direct DNA contact codons is predictive of outcome in CCT-treated PCNSL patients, and concomitant MUT -TP53 and MIR34A methylation are associated with poor PFS. Expand
Cell‐of‐origin determined by both gene expression profiling and immunohistochemistry is the strongest predictor of survival in patients with diffuse large B‐cell lymphoma
TLDR
To determine COO both by IHC and GEP is the strongest outcome predictor to identify DLBCL patients with the worst outcome, which was significant in multivariate analyses. Expand
Profiling of ribose methylations in ribosomal RNA from diffuse large B-cell lymphoma patients for evaluation of ribosomes as drug targets
TLDR
Signals of hypomethylation at several sites in patient-derived diffuse large B-cell lymphoma cell lines with a more severe perturbation in ABC-DLBCL compared to GBC- DLBCL are demonstrated. Expand
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