A Dual Program for Translation Regulation in Cellular Proliferation and Differentiation
Agonist-induced Conformational Changes at the Cytoplasmic Side of Transmembrane Segment 6 in the β2 Adrenergic Receptor Mapped by Site-selective Fluorescent Labeling*
- A. Jensen, F. Guarnieri, S. Rasmussen, F. Asmar, J. Ballesteros, U. Gether
- Biology, ChemistryJournal of Biological Chemistry
- 23 March 2001
The data suggest that activation of G protein-coupled receptors, which are activated by “diffusible” ligands, involves a structural rearrangement corresponding to the cytoplasmic part of transmembrane segment (TM) 6.
Structural basis for activation of G-protein-coupled receptors.
- U. Gether, F. Asmar, A. Meinild, S. Rasmussen
- Biology, ChemistryActa Pharmacologica et Toxicologica
- 1 December 2002
Using the beta2-adrenergic receptor as a model system, evidence is obtained for an evolutionary conserved activation mechanism where disruption of intramolecular interactions between TM3 and TM6 leads to a major conformational change of TM6 relative to the rest of the receptor.
Genome-wide profiling identifies a DNA methylation signature that associates with TET2 mutations in diffuse large B-cell lymphoma
The data suggest that TET2 mutations may cause aberrant methylation mainly of genes involved in hematopoietic development, which are silenced but poised for activation in human embryonic stem cells.
Frequent NFKBIE deletions are associated with poor outcome in primary mediastinal B-cell lymphoma.
NFKBIE aberrations are identified as a common genetic event across B-cell malignancies and NFKBIe deletions are highlighted as a novel poor-prognostic marker in PMBL.
Twin DNA Methylation Profiling Reveals Flare‐Dependent Interferon Signature and B Cell Promoter Hypermethylation in Systemic Lupus Erythematosus
Using the disease‐discordant twin model, genome‐wide DNA methylation changes in sorted CD4+ T cells, monocytes, granulocytes, and B cells in twin pairs with at least 1 SLE‐affected twin are investigated.
Dual inhibition of DNMTs and EZH2 can overcome both intrinsic and acquired resistance of myeloma cells to IMiDs in a cereblon‐independent manner
The data suggest that simultaneous inhibition of DNA methyl transferases and EZH2 leads to an extensive epigenetic reprogramming which allows myeloma cells to (re)gain sensitivity to IMiDs.
Hypermethylation of DAPK1 is an independent prognostic factor predicting survival in diffuse large B-cell lymphoma
Methylation of the death associated protein kinase (DAPK or DAPK1) gene and TP53 mutations are likely to have prognostic value in DLBCL and it is found that D APK1 promoter methylation was associated with shorter overall survival and disease-specific survival.
Profiling of ribose methylations in ribosomal RNA from diffuse large B-cell lymphoma patients for evaluation of ribosomes as drug targets
- N. Krogh, F. Asmar, C. Côme, H. F. Munch-Petersen, K. Grønbæk, H. Nielsen
- BiologyNAR Cancer
- 1 December 2020
Signals of hypomethylation at several sites in patient-derived diffuse large B-cell lymphoma cell lines with a more severe perturbation in ABC-DLBCL compared to GBC- DLBCL are demonstrated.