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Bacteriophage T4 Genome
- E. S. Miller, E. Kutter, G. Mosig, F. Arisaka, T. Kunisawa, W. Rüger
- BiologyMicrobiology and Molecular Biology Reviews
- 1 March 2003
T4 functional genomics will aid in the interpretation of these newly sequenced T4-related genomes and in broadening the understanding of the complex evolution and ecology of phages—the most abundant and among the most ancient biological entities on Earth.
Structural basis of Sec-independent membrane protein insertion by YidC
An insertion mechanism for single-spanning membrane proteins, in which the hydrophilic environment generated by the groove recruits the extracellular regions of substrates into the low-dielectric environment of the membrane is proposed.
Structure and morphogenesis of bacteriophage T4
- P. Leiman, S. Kanamaru, V. Mesyanzhinov, F. Arisaka, M. Rossmann
- BiologyCellular and Molecular Life Sciences CMLS
- 1 November 2003
Bacteriophage T4 is one of the most complex viruses, which consists of a protein shell encapsidating a 172-kbp double-stranded genomic DNA, a ‘tail,’ and fibers, attached to the distal end of the tail.
Silk Fibroin of Bombyx mori Is Secreted, Assembling a High Molecular Mass Elementary Unit Consisting of H-chain, L-chain, and P25, with a 6:6:1 Molar Ratio*
- S. Inoue, K. Tanaka, F. Arisaka, S. Kimura, K. Ohtomo, S. Mizuno
- ChemistryThe Journal of Biological Chemistry
- 22 December 2000
Inaccessibility of biotinylated concanavalin A to the native elementary unit and partial dissociation of the elementary unit after incubation with excess N-glycosidase F or endoglycosidases H suggest that a single molecule of P25 is located internally and plays an important role in maintaining integrity of the complex.
Atg38 is required for autophagy-specific phosphatidylinositol 3-kinase complex integrity
Atg38 provides a physical linkage between the Vps15–Vps34 and Atg14–Vps30 subcomplexes to facilitate PI3-kinase complex I formation.
Balance between Distinct HP1 Family Proteins Controls Heterochromatin Assembly in Fission Yeast
It is demonstrated that a proper balance between Swi6 and Chp2 is critical for heterochromatin assembly and provides novel insight into the distinct and cooperative functions of multiple HP1 family proteins in the formation of higher-order chromatin structure.
Structure of the cell-puncturing device of bacteriophage T4
A crystal structure of the (gp5–gp27)3 321K complex is presented, determined to 2.9 Å resolution and fitted into a cryo-electron microscopy map at 17 resolution of the baseplate-tail tube assembly, which may serve as a channel for DNA ejection.
Morphogenesis of the T4 tail and tail fibers
The baseplate assembly process has been recently reexamined in detail in a precise system involving recombinant proteins and showed that the sequential association of the subunits of the baseplate wedge is based on the induced-fit upon association of each subunit.
Nuclear Transport of the Major Capsid Protein Is Essential for Adeno-Associated Virus Capsid Formation
Adeno-associated virus capsids are composed of three proteins, VP1, VP2, and VP3, and it is shown that this fusion protein could form VLP, indicating that VP3 has sufficient information for VLP formation and that VP2 is necessary only for nuclear transfer of the capsid proteins.