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Orexin A stimulates cortisol secretion from human adrenocortical cells through activation of the adenylate cyclase-dependent signaling cascade.
TLDR
The findings suggest that orexins selectively stimulate glucocorticoid secretion from human adrenocortical cells, acting through OX1-R coupled with the adenylate cyclase-dependent signaling pathway. Expand
Saturation prostate needle biopsy and prostate cancer detection at initial and repeat evaluation.
TLDR
As primary biopsy, SPBX does not increase the PCa detection rate compared with an 18-core scheme; in the case of rebiopsy, the SPBx is a recommended method as the PCA detection rate is doubled compared with 12- or 18- core biopsy sets. Expand
Does color Doppler sonography improve the clinical assessment of patients with acute scrotum?
TLDR
CDS is an indispensable imaging modality for the clinical assessment of patients with acute scrotum; however, the informations it can afford are operator-dependent and have to be supported by the history and physical exam of the patient. Expand
PTH and PTH-related peptide enhance steroid secretion from human adrenocortical cells.
TLDR
It is concluded that PTH and PTH- RP exert a sizeable secretagogue action on the human adrenal cortex, probably acting through the PTH/PTH-RP receptor coupled with both adenylate cyclase/PKA- and PLC/PKC-dependent signaling cascades. Expand
Human pheochromocytomas express orexin receptor type 2 gene and display an in vitro secretory response to orexins A and B.
TLDR
It is suggested that orexins stimulate catecholamine secretion from human pheochromocytomas, acting through OX2-R coupled to the PLC-PKC signaling pathway. Expand
Functional evaluation of the urinary tract by color-Doppler ultrasonography (CDU) in 100 patients with renal colic.
TLDR
CDU in patients with renal colic and/or pelvicalicectasis improves the diagnostic accuracy of US in distinguishing between obstructive and non-obstructive dilatation and combined with unenhanced CT, CDU has a 100% sensitivity and specificity. Expand
Correlation of testicular volume, histology and LHRH test in adolescents with idiopathic varicocele.
TLDR
Lowesticular volume and gonadotropin response to LHRH stimulation were evaluated preoperatively and compared to the histological findings from bilateral testicular biopsies and decreased testicular volume does not seem to be a reliable predictor of early testicular damage. Expand
Cerebellin enhances in vitro secretory activity of human adrenal gland.
TLDR
The present findings allow us to conclude that cerebellin exerts a sizable secretagogue action on both cortex and medulla of human adrenals, and the peptide directly stimulates catecholamine release via the adenylate cyclase/protein kinase A-dependent signaling pathway. Expand
Bone density and skeletal metabolism in patients with orthotopic ileal neobladder.
TLDR
In patients with ileal neobladder, a mild metabolic acidosis is responsible for an increased bone turnover and lower bone mass and a decrease over time in the absorption capacity of the ileale pouch might result in calcium malabsorption, which represents an additional risk factor for reduced bone mass in these patients. Expand
Morbidity after transperineal prostate biopsy in 3000 patients undergoing 12 vs 18 vs more than 24 needle cores.
TLDR
Clinical complications after transperineal prostate biopsy occurred in 40.2% of the patients, but only 1. Expand
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