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Long-Distance Retrograde Effects of Botulinum Neurotoxin A
TLDR
It is demonstrated that catalytically active BoNT/A is retrogradely transported by central neurons and motoneurons and is then transcytosed to afferent synapses, in which it cleaves SNAP-25. Expand
Evidence for Anterograde Transport and Transcytosis of Botulinum Neurotoxin A (BoNT/A)
TLDR
It is demonstrated that catalytically active BoNT/A is anterogradely transported from the eye to the SC and transcytosed to tectal synapses, which is important for a more complete understanding of the mechanisms of action of Bo NT/A. Expand
The Timing of the Excitatory-to-Inhibitory GABA Switch Is Regulated by the Oxytocin Receptor via KCC2
TLDR
KCC2 is identified as a key target of oxytocin in postnatal events that may be linked to pathogenesis of neurodevelopmental disorders and increased susceptibility to seizures observed in adult Oxtr-null mice. Expand
Microvesicles released from microglia stimulate synaptic activity via enhanced sphingolipid metabolism
TLDR
Analysis of spontaneous release of glutamate in neurons exposed to MVs found a dose‐dependent increase in miniature excitatory postsynaptic current (mEPSC) frequency without changes in mEpsC amplitude, and identifies microglia‐derived MVs as a new mechanism by which microglian influence synaptic activity. Expand
Cracking Down on Inhibition: Selective Removal of GABAergic Interneurons from Hippocampal Networks
TLDR
SAVAs are identified as an effective tool to eliminate GABAergic neurons from neuronal circuits underpinning high-order behaviors and cognition, and whose manipulation can recapitulate pathogenic cascades of epilepsy and other neuropsychiatric illnesses. Expand
Leucine-Rich Repeat Kinase 2 Binds to Neuronal Vesicles through Protein Interactions Mediated by Its C-Terminal WD40 Domain
TLDR
A domain-based pulldown approach combined with mass spectrometric analysis identified LRRK2 as being part of a highly specific protein network involved in synaptic vesicle trafficking, and demonstrated a critical role of the WD40 domain within L RRK2 function. Expand
Phenotypic Changes, Signaling Pathway, and Functional Correlates of GPR17-expressing Neural Precursor Cells during Oligodendrocyte Differentiation*
TLDR
GPR17 is a new marker of these transition stages of NG2+ OPCs and point to uracil nucleotides and cysLTs as main extrinsic local regulators of these cells under physiological conditions and during myelin repair. Expand
A reappraisal of the central effects of botulinum neurotoxin type A: by what mechanism?
TLDR
The possibility that retrograde axonal transport of catalytically active BoNT/A may explain at least some of its effects at the level of central circuits is discussed. Expand
Maternal Immune Activation Delays Excitatory-to-Inhibitory Gamma-Aminobutyric Acid Switch in Offspring
TLDR
Evidence is provided that maternal immune activation hits a key neurodevelopmental process, the excitatory-to-inhibitory gamma-aminobutyric acid switch; defects in this switch have been unequivocally linked to diseases such as autism spectrum disorder or epilepsy. Expand
Active endocannabinoids are secreted on extracellular membrane vesicles
TLDR
It is demonstrated that microglial extracellular vesicles carry on their surface N‐arachidonoylethanolamine (AEA), which is able to stimulate type‐1 cannabinoid receptors (CB1), and inhibit presynaptic transmission, in target GABAergic neurons. Expand
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