• Publications
  • Influence
fMRI activation during spike and wave discharges in idiopathic generalized epilepsy.
TLDR
The presence of a thalamic BOLD response in most patients provided, for the first time in a group of human patients, confirmation of the evidence ofThalamic involvement seen in animal models, and brings a new light to the pathophysiolocal mechanisms generating GSW. Expand
Intrinsic epileptogenicity of human dysplastic cortex as suggested by corticography and surgical results
TLDR
It is concluded that CDyLs are highly and intrinsically epilepsyptogenic, and that intraoperative ECoG identification of this intrinsically epileptogenic dysplastic cortical tissue is crucial to decide the extent of excision for best seizure control. Expand
The role of the limbic system in experiential phenomena of temporal lobe epilepsy
TLDR
Patients with medically intractable temporal lobe epilepsy who were investigated with chronic, stereotaxically implanted intracerebral electrodes reported perceptual experiential phenomena that mainly consisted of perceptual hallucinations or illusions, memory flashbacks, illusions of familiarity, forced thinking, or emotions. Expand
Anatomic basis of amygdaloid and hippocampal volume measurement by magnetic resonance imaging
TLDR
A protocol to measure the volumes of the amygdala and as much of the hippocampus using high-resolution MRI to clarify the role of this structure in the pathogenesis of temporal lobe epilepsy is developed. Expand
The spectrum of SCN1A-related infantile epileptic encephalopathies.
TLDR
Knowing of an expanded spectrum of epileptic encephalopathies associated with SCN1A mutations allows earlier diagnostic confirmation for children with these devastating disorders, including cryptogenic generalized epilepsy and cryptogenic focal epilepsy. Expand
Hypothalamic hamartomas and ictal laughter: Evolution of a characteristic epileptic syndrome and diagnostic value of magnetic resonance imaging
TLDR
The epileptic syndrome associated with hypothalamic hamartomas characteristically begins in infancy with laughing seizures and between the ages of 4 and 10 years, the clinical and electroencephalographic features of secondary generalized epilepsy develop. Expand
Complex visual hallucinations. Clinical and neurobiological insights.
TLDR
It is suggested that perturbation of a distributed matrix may explain the production of similar, complex mental phenomena by relatively blunt insults at disparate sites. Expand
MRI volumetric measurement of amygdala and hippocampus in temporal lobe epilepsy
TLDR
MRI volumetric measurements of the amygdala, the hippocampal formation, and the anterior temporal lobe in a group of 30 patients with intractable temporal lobe epilepsy and in seven patients with extratemporal lobe foci showed lateralization of measurable atrophy consistent with that derived from extracranial and intracranial EEG examinations. Expand
Temporal lobe epilepsy caused by domoic acid intoxication: Evidence for glutamate receptor–mediated excitotoxicity in humans
TLDR
The seizures following acute domoic acid intoxication, the postmortem pathology, and the fact that temprol lobe epilepsy developed 1 year after intoxication indicate that the human hippcampus is also vulnerable to kainate receptor excitotoxicity, and provide strong evidence supporting the role of excitOToxic injury in epileptogenesis. Expand
Autosomal dominant frontal epilepsy misdiagnosed as sleep disorder
TLDR
A distinctive epilepsy syndrome in six families is described, which is the first partial epilepsy syndrome to follow single gene inheritance and is ideal for identification of partial epilepsy genes. Expand
...
1
2
3
4
5
...