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Structure, Function, and Activator-Induced Conformations of the CRSP Coactivator
It is reported that affinity-purified ARC consists of two distinct multisubunit complexes: a larger complex, denoted ARC-L, and a smaller coactivator, CRSP, suggesting that CRSP may potentiate transcription via specific activator-induced conformational changes. Expand
Three-dimensional structure of the human TFIID-IIA-IIB complex.
The structures of human TFIID and the TFIIDs-IIA-IIB complex that were obtained by electron microscopy and image analysis to 35 angstrom resolution are presented. Expand
Femtosecond time‐resolved spectroscopy of the primary photochemistry of phytochrome
Time-resolved absorption spectra of Pr phytochrome were obtained using a regeneratively amplified femtosecond titanium : sapphire laser system. The early time transient absorption spectra areExpand
Resonance raman analysis of chromophore structure in the lumi-R photoproduct of phytochrome.
A four-state model is presented to explain the chromophore structural changes in Pr, lumi-R, and Pfr that uses hydrogen bonding to the surrounding protein to stabilize the high-energy Pfr C15 = C16, C14-C15, E,anti Chromophore structure. Expand
Probing the photoreaction mechanism of phytochrome through analysis of resonance Raman vibrational spectra of recombinant analogues.
The strong nonbonded interactions of the C- and D-ring methyl groups in the C(15)-E,anti P(fr) chromophore structure indicated by the intense 814 cm(-1) C( 15) HOOP mode suggest that the excited state of P(r) and its photoproduct states are strongly coupled. Expand
An automated, sheathless capillary electrophoresis‐mass spectrometry platform for discovery of biomarkers in human serum
The utility of the capillary electrophoresis‐mass spectrometry method for the discovery of patterns of biomarkers in serum is demonstrated, with the accuracy of the assignment was 95%, demonstrating the utility of this technique. Expand
Do Biochemical Exaptations Link Evolution of Plant Defense and Pollination Systems? Historical Hypotheses and Experimental Tests with Dalechampia Vines
Chemical analyses and bioassays support two hypotheses and indicate that, in this system, biochemical exaptations have played a major role in the evolution of plant-insect relationships, adaptations reducing herbivory have affected the evolutionof plant-pollinator relationships, and adaptations for pollination have affectedThe evolution of plants-herbivore relationships. Expand
Health Financing and Pharmaceutical Policy Reform in the Countries of Central and Eastern Europe
The objective of this report is to provide an assessment of the reform process of the health care sector in the Countries of Central and Eastern Europe (CCEE). It shall assess the overall directionExpand