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Immune function of microglia
- F. Aloisi
- 1 November 2001
The signals regulatingmicroglia innate immune functions, the role of microglia in antigen presentation, and their possible involvement in the development of CNS immunopathology are focused on.
Astrocytes are active players in cerebral innate immunity.
Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology.
Data support an immunopathogenetic mechanism whereby B-cell follicles developing in the multiple sclerosis meninges exacerbate the detrimental effects of humoral immunity with a subsequent major impact on the integrity of the cortical structures.
Detection of Ectopic B‐cell Follicles with Germinal Centers in the Meninges of Patients with Secondary Progressive Multiple Sclerosis
- B. Serafini, Barbara Rosicarelli, R. Magliozzi, E. Stigliano, F. Aloisi
- Biology, MedicineBrain pathology
- 1 April 2004
Lymphoid follicle‐like structures containing B‐cells, T‐cells and plasma cells, and a network of follicular dendritic cells producing CXCL13 were observed in the cerebral meninges of 2 out of 3 patients with secondary progressive MS, but not in relapsing remitting and primary progressive MS.
Lymphoid neogenesis in chronic inflammatory diseases
Recent progress in several aspects of lymphoid neogenesis are discussed, focusing on the similarities with lymphoid tissue development, the mechanisms of induction, functional competence and pathophysiological significance, and how these issues might eventually lead to new strategies to target immunopathological processes.
Meningeal inflammation is widespread and linked to cortical pathology in multiple sclerosis.
The findings suggest that meningeal infiltrates may play a contributory role in the underlying subpial grey matter pathology and accelerated clinical course, which is exacerbated in a significant proportion of cases by the presence of B cell follicle-like structures.
A Gradient of neuronal loss and meningeal inflammation in multiple sclerosis
Evaluated the cellular substrates of the cortical damage to understand the role of meningeal inflammation in MS pathology and identified ectopic B‐cell follicle‐like structures in the meninges.
Dysregulated Epstein-Barr virus infection in the multiple sclerosis brain
- B. Serafini, Barbara Rosicarelli, F. Aloisi
- BiologyThe Journal of experimental medicine
- 26 November 2007
Findings from this study are interpreted as evidence that EBV persistence and reactivation in the CNS play an important role in MS immunopathology.
Regulation of T-cell responses by CNS antigen-presenting cells: different roles for microglia and astrocytes.