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Everted gut sac model as a tool in pharmaceutical research: limitations and applications
Objectives  This review discusses the limitations and applications of the everted gut sac model in studying drug absorption, metabolism, and interaction.
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Modulation of CYP2D6 and CYP3A4 metabolic activities by Ferula asafetida resin
Present study investigated the potential effects of Ferula asafetida resin on metabolic activities of human drug metabolizing enzymes: CYP2D6 and CYP3A4. Dextromethorphan (DEX) was used as a markerExpand
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Hepatoprotective activity of Lepidium sativum seeds against D-galactosamine/lipopolysaccharide induced hepatotoxicity in animal model
BackgroundFulminant hepatic failure (FHF) is clinical syndrome with very poor prognosis and high mortality there is urgent need for the development of safe and non-toxic hepatoprotective agents forExpand
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Solid dispersions: a strategy for poorly aqueous soluble drugs and technology updates
Introduction: Present article reviews solid dispersion (SD) technologies and other patented inventions in the area of pharmaceutical SDs, which provide stable amorphous SDs. Areas covered: The reviewExpand
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Oral bioavailability enhancement and hepatoprotective effects of thymoquinone by self-nanoemulsifying drug delivery system.
Thymoquinone (TQ) is a poorly water soluble bioactive compound which shows poor oral bioavailability upon oral administration. Due to poor aqueous solubility and bioavailability of TQ, variousExpand
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Momordica charantia polysaccharides ameliorate oxidative stress, inflammation, and apoptosis in ethanol-induced gastritis in mucosa through NF-kB signaling pathway inhibition.
This study investigated the therapeutic role of polysaccharides from M. charantia and their mechanism of action against ethanol-induced gastric ulcers in rats. Their effects were determined throughExpand
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Environmentally Responsive Ophthalmic Gel Formulation of Carteolol Hydrochloride
Environmentally responsive gel formulation for ocular controlled delivery of carteolol hydrochloride (HCl) was developed in an attempt to improve ocular bioavailability and hence decrease itsExpand
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Effect of black seed on dextromethorphan O- and N-demethylation in human liver microsomes and healthy human subjects.
OBJECTIVE To investigate the effects of black seed on the metabolic activities of CYP3A4 and CYP2D6 in human liver microsomes and in human subjects using dextromethorphan as a probe drug. METHODSExpand
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Rhodamine-123: a p-glycoprotein marker complex with sodium lauryl sulfate.
Aim of this study was to investigate the role of sodium lauryl sulfate (SLS) as P-glycoprotein inhibitor. The everted rat gut sac model was used to study in-vitro mucosal to serosal transport ofExpand
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Formulation and characterization of novel soft nanovesicles for enhanced transdermal delivery of eprosartan mesylate
The objective of the present work was to formulate, optimize and evaluate the potential of novel soft nanovesicles i.e. nano-transfersomes, containing eprosartan mesylate (EM) for transdermalExpand
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