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Hepatoprotective activity of Lepidium sativum seeds against D-galactosamine/lipopolysaccharide induced hepatotoxicity in animal model
- M. Raish, Ajaz Ahmad, M. Ansari
- Biology, MedicineBMC Complementary and Alternative Medicine
- 3 December 2016
The data suggests that pretreatment of LSEE down regulates the caspase 3 and up-regulates the BCl2 protein expression and encourages hepatoprotective activity by down-regulating mRNA expression of iNOS and HO-1.
Solid dispersions: a strategy for poorly aqueous soluble drugs and technology updates
- M. Alam, Raisuddin Ali, F. Al-Jenoobi, A. Al-Mohizea
- ChemistryExpert opinion on drug delivery
- 19 October 2012
Binary and ternary SDs are found to be more stable and provide better enhancement of solubility or dissolution of poorly water-soluble drugs and surfactants and polymers provide stability against re-crystallization of SDs, surfactants also improve solubilities and dissolution of drug.
Oral bioavailability enhancement and hepatoprotective effects of thymoquinone by self-nanoemulsifying drug delivery system.
Modulation of CYP2D6 and CYP3A4 metabolic activities by Ferula asafetida resin
Everted gut sac model as a tool in pharmaceutical research: limitations and applications
The limitations and applications of the everted gut sac model in studying drug absorption, metabolism, and interaction are discussed.
Pharmacodynamic study of eprosartan mesylate-loaded transfersomes Carbopol® gel under Dermaroller® on rats with methyl prednisolone acetate-induced hypertension.
Environmentally Responsive Ophthalmic Gel Formulation of Carteolol Hydrochloride
The developed in situ gel formulation showed potential for use as delivery systems with superior ocular bioavailability of carteolol HCl and showed significantly improved bioavailability compared with the commercial aqueous solution.
Effect of black seed on dextromethorphan O- and N-demethylation in human liver microsomes and healthy human subjects.
Black seed significantly inhibited CYP2D6 and CYP3A4 mediated metabolism of DEX in human liver microsomes and healthy human volunteers indicating that it has the potential to interact with CYP4A4 and CYD6 substrates.
Thymoquinone treatment modulates the Nrf2/HO-1 signaling pathway and abrogates the inflammatory response in an animal model of lung fibrosis
It is proposed that the Nrf2/Ho-1 signaling pathway is a principal target for TQ protective effect against BMILF in rats and TQ decreases inflammatory oxidative stress possibly through the modulation of nuclear factor Kappa-B (NF-κB) and thereby minimization of collagen deposition in the lung.
Distribution of selected gene polymorphisms of UGT1A1 in a Saudi population
Evaluated genotype and allele frequencies of certain UDP-glucuronosyltransferase 1A1 (UGT1A1) variants in an Arab population indicate that Saudis harbor some important UGT1A 1 mutations known to affect enzyme activity.