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Targeting multiple signaling pathways by green tea polyphenol (-)-epigallocatechin-3-gallate.
The modulations of important signaling events by EGCG are discussed and their implications in cancer management are discussed.
Anthocyanin‐ and hydrolyzable tannin‐rich pomegranate fruit extract modulates MAPK and NF‐κB pathways and inhibits skin tumorigenesis in CD‐1 mice
Because PFE is capable of inhibiting conventional as well as novel biomarkers of TPA‐induced tumor promotion, it may possess chemopreventive activity in a wide range of tumor models and an in‐depth study to define active agent in PFE capable of affording antitumor‐promoting effect is warranted.
Cannabinoid receptor as a novel target for the treatment of prostate cancer.
The results suggest that WIN-55,212-2 or other non-habit-forming cannabinoid receptor agonists could be developed as novel therapeutic agents for the treatment of prostate cancer.
Inhibition of UVB-induced oxidative stress-mediated phosphorylation of mitogen-activated protein kinase signaling pathways in cultured human epidermal keratinocytes by green tea polyphenol
It is demonstrated that pretreatment of NHEK with (-)-epigallocatechin-3-gallate (EGCG), an antioxidant from green tea, inhibits UVB-induced hydrogen peroxide production and H(2)O(2)-mediated phosphorylation of MAPK signaling pathways, suggesting that EGCG could be useful in attenuation of oxidative stress-mediated and MAPK-caused skin disorders in humans.
Cancer chemoprevention through dietary antioxidants: progress and promise.
An extensive analysis of the key findings from studies on the effects of dietary antioxidants such as tea polyphenols, curcumin, genistein, resveratrol, lycopene, pomegranate, and lupeol against cancers of the skin, prostate, breast, lung, and liver is presented.
Cannabinoid Receptor Agonist-induced Apoptosis of Human Prostate Cancer Cells LNCaP Proceeds through Sustained Activation of ERK1/2 Leading to G1 Cell Cycle Arrest*
It is suggested that cannabinoid receptor agonists should be considered as novel agents for the management of prostate cancer because of the mechanistic basis of their effects on cell growth and induction of apoptosis.
Pomegranate fruit juice for chemoprevention and chemotherapy of prostate cancer.
Pomegranate fruit extract inhibits prosurvival pathways in human A549 lung carcinoma cells and tumor growth in athymic nude mice.
It is suggested that pomegranate fruit extract can be a useful chemopreventive/chemotherapeutic agent against human lung cancer.
A dietary anthocyanidin delphinidin induces apoptosis of human prostate cancer PC3 cells in vitro and in vivo: involvement of nuclear factor-kappaB signaling.
Evidence is provided that delphinidin could be developed as an agent against human PCa and significant decrease in the expression of NF-kappaB/p65, Bcl2, Ki67, and PCNA was found in mice implanted with PC3 cells.