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Alterations in the regulation of androgen-sensitive Cyp 4a monooxygenases cause hypertension
It is concluded that the androgen-mediated regulation of Cyp 4a arachidonate monooxygenases is an important component of the renal mechanisms that control systemic blood pressures. Expand
CYP86A1 from Arabidopsis thaliana encodes a cytochrome P450-dependent fatty acid omega-hydroxylase.
Genomic organization analyzed by Southern blot suggested a single gene encoding CYP86A1 in A. thaliana, which was found to catalyze the omega-hydroxylation of saturated and unsaturated fatty acids with chain lengths from C12 to C18 but not of hexadecane. Expand
The Innate Immunity of a Marine Red Alga Involves Oxylipins from Both the Eicosanoid and Octadecanoid Pathways1[w]
The dual nature of oxylipin metabolism in this alga suggests that early eukaryotes featured both animal- (eicosanoids) and plant-like (octadecanoids) oxylIPins as essential components of innate immunity mechanisms. Expand
Free Fatty Acids and Methyl Jasmonate Trigger Defense Reactions in Laminaria digitata.
This study supports the notion that lipid oxidation signaling plays a key role in defense induction in marine brown algae. Expand
Requirement for omega and (omega;-1)-hydroxylations of fatty acids by human cytochromes P450 2E1 and 4A11.
Human liver microsomes and recombinant human P450 have been used as enzyme source in order to better understand the requirement for the optimal rate of omega and (omega;-1)-hydroxylations of fattyExpand
Involvement of cytochrome P450 2E1 in the (omega-1)-hydroxylation of oleic acid in human and rat liver microsomes.
It can be ascertained that P450 2E1 is the main enzyme involved in the (omega-1)-hydroxylation of oleic acid, which was shown to be mainly catalyzed by P450 4A enzymes in human liver microsomes. Expand
Interspecies variations in fatty acid hydroxylations involving cytochromes P450 2E1 and 4A.
The liver microsomal fractions of seven mammalian species, catalyzed the hydroxylation of saturated and unsaturated fatty acids to the corresponding omega and (omega-1)-hydroxylated derivatives, while stearic acid was not metabolized and can be used as a specific and sensitive method to measure the level of CYP2E1 induction in humans and various animals. Expand
Liquid chromatography–mass spectrometry and gas chromatography–mass spectrometry of ω- and (ω-1)-hydroxylated metabolites of elaidic and oleic acids in human and rat liver microsomes
In order to characterize the nature of the active site of cytochrome P450 2E1, the metabolism of various fatty acids with cis/trans geometric configurations has been investigated. A system couplingExpand
Fatty acid omega- and (omega-1)-hydroxylation in experimental alcoholic liver disease: relationship to different dietary fatty acids.
A significant increase in (omega-1)-hydroxylation products was seen in rats fed diets containing significant amounts of linoleic acid (i.e., palm oil and corn oil) and no correlation was seen between the omega-hydroxyation products and CYP2E1 activity. Expand
Involvement of cytochrome P 450 2 E 1 in the ( v – 1 )-hydroxylation of oleic acid in human and rat liver microsomes
In vitro techniques have been used to investigate the nature of microsomal cytochrome P450 involved in the metabolism of oleic acid, a physiological monounsaturated fatty acid. Like lauric acid,Expand