Heme oxygenase-1 mediates the anti-allergic actions of quercetin in rodent mast cells
- M. Matsushima, K. Takagi, T. Kawabe
- Biology, MedicineInflammation Research
- 24 April 2009
Results strongly suggest that quercetin exerted anti-allergic actions via activation of Nrf2-HO-1 pathway.
Involvement of multidrug resistance-associated protein 2 (ABCC2/Mrp2) in biliary excretion of micafungin in rats.
- F. Abe, J. Ueyama, T. Hasegawa
- Biology, MedicineLife Science
- 15 August 2008
FR901483, a novel immunosuppressant isolated from Cladobotryum sp. No. 11231. Taxonomy of the producing organism, fermentation, isolation, physico-chemical properties and biological activities.
- K. Sakamoto, E. Tsujii, M. Okuhara
- Biology, ChemistryJournal of antibiotics (Tokyo. )
- 25 January 1996
FR901483 exerts a potent immunosuppressive activity in vitro and significantly prolongs graft survival time in the rat skin allograft model.
FR235222, a fungal metabolite, is a novel immunosuppressant that inhibits mammalian histone deacetylase (HDAC) II. Biological activities in animal models.
Results showed potential clinical use of this compound as a new type immunosuppressant in the fields of autoimmune diseases and organ transplantations.
FR235222, a fungal metabolite, is a novel immunosuppressant that inhibits mammalian histone deacetylase (HDAC). I. Taxonomy, fermentation, isolation and biological activities.
A cyclic tetrapeptide FR235222, a novel immunosuppressant, has been isolated from the fermentation broth of a fungus and showed potent and selective inhibitory effects on both T cell proliferation and lymphokine production.
Identification and isolation of splenic tissue-resident macrophage sub-populations by flow cytometry
- Satoshi Fujiyama, C. Nakahashi-Oda, F. Abe, Yaqiu Wang, Kazuki Sato, A. Shibuya
- Biology, MedicineInternational Immunology
- 25 September 2018
Isolation of splenic macrophage subpopulations using an enzyme cocktail using an enzymes cocktail shows good separation between splenic and non-splenic populations.
FR220897 and FR220899, Novel Antifungal Lipopeptides from Coleophoma empetri No. 14573
- Ryuichi Kanasaki, F. Abe, Y. Hori
- BiologyJournal of antibiotics (Tokyo. )
- 1 March 2006
Novel antifungal lipopeptides, FR220897 and FR220899, were isolated from the fermentation broth of a fungal strain No. 14573 and showed antif fungus activities against Aspergillus fumigatus and Candida albicans attributed to inhibition of 1-3-β-glucan synthesis.
Glycoprotein nmb Is Exposed on the Surface of Dormant Breast Cancer Cells and Induces Stem Cell-like Properties.
- Chen Chen, Yukari Okita, Mitsuyasu Kato
- BiologyCancer Research
- 17 September 2018
It is suggested that cell surface expression of GPNMB could serve as a marker and promising therapeutic target of breast cancer cells with stem cell-like properties.
Role of Plasma Proteins in Pharmacokinetics of Micafungin, an Antifungal Antibiotic, in Analbuminemic Rats
- F. Abe, J. Ueyama, T. Hasegawa
- Biology, MedicineAntimicrobial Agents and Chemotherapy
- 30 June 2008
Results suggest that HDL and gamma globulin contribute to the pharmacokinetics of micafungin.
CD300a blockade enhances efferocytosis by infiltrating myeloid cells and ameliorates neuronal deficit after ischemic stroke
- C. Nakahashi-Oda, Satoshi Fujiyama, A. Shibuya
- Biology, MedicineScience immunology
- 15 October 2021
It is shown that mice deficient in the phosphatidylserine receptor CD300a, which is highly expressed on brain myeloid cells including Ly6Chi monocytes, exhibited ameliorated neurological deficit after middle cerebral artery occlusion (MCAO), revealing an important role of efferocytosis in the super-acute phase of ischemic stroke pathology.
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