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Treatment of age-related memory complaints with Ginkgo biloba extract: a randomized double blind placebo-controlled study.
TLDR
The results indicate that the use of Ginkgo extracts in elderly individuals with cognitive impairment might be promising and further research using both subjective and objective measurements is recommended. Expand
Formation of DNA adducts by the anticancer drug carboplatin: different nucleotide sequence preferences in vitro and in cells.
TLDR
The immunocytochemical detection of the platinum-DNA modifications showed a pattern similar to that found for the various bifunctional adducts: the initially low levels slowly increased to maximum values within 7-12 h and then slowly decreased. Expand
Detection of platinum-DNA adducts by 32P-postlabelling.
TLDR
A sensitive 32P-postlabeling method for the detection of bifunctional intrastrand crosslinks d(Pt-GpG) and d(ApG) in DNA in vitro and in vivo found good correlations with existing methods (AAS, immunocytochemistry and ELISA). Expand
Effects of ozone, hexachlorobenzene, and bis(tri-n-butyltin)oxide on natural killer activity in the rat lung.
TLDR
This work has developed and validated a method to measure the effects of (toxic) substances on NK activity in rat lung and validated the reliability of the test with well-known NK activity stimulators and inhibitors. Expand
Hyperthermia enhances the cytotoxicity and platinum-DNA adduct formation of lobaplatin and oxaliplatin in cultured SW 1573 cells
TLDR
Results seem to confirm that an increase in platinum-DNA adduct formation is involved in the in vitro thermal enhancement of cytotoxicity, and warrants further in vivo investigations. Expand
In vitro formation of DNA adducts by cisplatin, lobaplatin and oxaliplatin in calf thymus DNA in solution and in cultured human cells.
TLDR
The 32P-postlabelling technique has been shown to be appropriate for adduct analysis, not only for the classical Pt compounds cisplatin and carboplatin but also for novel platinum compounds like lobaplatinand oxaliplatin. Expand
The formation and persistence of carboplatin-DNA adducts in rats
TLDR
Data indicate that in the first few hours after carboplatin treatment, no preference for the formation of Pt-GG adducts was observed, which confirms the earlier observations obtained with cultured cells. Expand
Drug-induced DNA modification in buccal cells of cancer patients receiving carboplatin and cisplatin combination chemotherapy, as determined by an immunocytochemical method: interindividual variation
TLDR
It is concluded that determination of the extent of platinum-induced DNA modification might be helpful in predicting the tumor response in cancer patients. Expand
Selective intra-arterial infusion of high-dose cisplatin in patients with advanced head and neck cancer results in high tumor platinum concentrations and cisplatin-DNA adduct formation
TLDR
The data suggest that the high platinum levels achieved by selective IA infusion were sufficient to produce enough interaction with radiotherapy to cause a 92% CR rate. Expand
The formation and repair of cisplatin-DNA adducts in wild-type and cisplatin-resistant L1210 cells: comparison of immunocytochemical determination with detection in isolated DNA.
TLDR
Differences in induced DNA platination levels, rather than in repair, are responsible--at least in part--for the differences in cisplatin resistance. Expand
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