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OBJECTIVES to examine coagulation, fibrinolysis, and platelet activity in patients with peripheral vascular disease (PVD). DESIGN fifty consecutive PVD patients and 50 healthy volunteers. (Prospective comparative study.) MATERIALS AND METHODS P-selectin expression in non-fixed, whole blood was measured flow cytometrically on non-stimulated and ADP- and(More)
Platelet volume has been reported to be increased in vascular disease. Therefore, we studied the relationship of mean platelet volume and platelet count as well as flow cytometrically measured platelet size and platelet function in 50 patients with peripheral arterial disease and 50 healthy volunteers. Platelet activation was measured by P-selectin(More)
BACKGROUND Dysbalance of the coagulation and fibrinolysis system was suspected to be a further risk factor for the progression of peripheral occlusive arterial disease (POAD). Reports on disturbed platelet function in advanced disease, however, were contradictory. Therefore, we studied haemostasis parameters and platelet function in symptomatic patients(More)
BACKGROUND The finding that platelets of patients with peripheral occlusive arterial disease (POAD) circulate in an activated state prompted us to study platelet signal transduction. We hypothesised that platelet hyperreactivity is caused by changes in intracellular signalling. METHODS EXPERIMENTAL DESIGN a single blood sample was taken from the(More)
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