F. Ya. Nazmetdinov

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For this purpose we have synthesized a series of 13-(halogenoacyl)hydrazides of 2-chloroand 2-anilino-5,6,7,8-tetrahydroquinoline-4-carboxylic acids (IIa-IIc) by reactions of hydrazides Ia and Ib [2] with chloroanhydrides of the corresponding carboxylic acids in glacial acetic acid in the presence of anhydrous sodium acetate. Acylhydrazies I Ia I Ic appear(More)
2-Aroylpyridyl amides of aroylpyruvic acids were found to exhibit the antiinflammatory and analgesic activity at rather low toxicity [I ]. Of interest is the study of pharmacological effect of 29 pyridyl amides as a function of the substituent nature in the pyridine moiety. Thus we synthesized 2-(6-methyl)and 2(5-bromo)pyridyl amides of aroylpyruvic acids ((More)
As reported, 2-arylarnino-6-methyland 4,6-dimethylnicotinic acid amides exhibit high anticonvulsive activity [1, 2], while 2-arylamino-5,6,7,8-tetrahydroquinoline-3-carboxylic acid amides show analgesic and antilnflammatory activity [3]. It was therefore of interest to study the properties of previously unreported compounds with close structures,(More)
IR spectrum, vma x, cm 1 CornYield, M.p., Empirical pound % *C Rf* formula Amide Amide II I NH2 The tH NMR spectrum of amide VI shows two singlets at 0.88 and 1.00 ppm (6H, 2CH3), a multiplet at 2.45 ppm (2H, CH2 in position 6 of pyrindine), a broadened signal from methine group at 2.45 ppm, a multiplet at 2 .583.00 ppm (4H, 2CH2 in positions 5 and 7 of(More)
Anthranilic acid hydrazides exhibit antistaphylococcus [ I ] and antiaggregation activity with respect to blood plasma thrombocytes [2]. They also can be used for the syntheses of nitrogen-containing heterocycles exhibiting various pharmacological effects [3]. Aroylpyruvic acid hydrazides exhibit a bacteriostatic effect against Staphylococcus aureus and(More)
Previously we reported on the synthesis and characterization of a series of alkylamides of 6-methyl-4,6-dimethyl-2-arylaminonicotinic acids [1, 2] and 2-arylamino5,6,7,8-tetrahydroquinoline-3-earboxylic acids [3], which showed analgesic, anticonvulsive, and antiinflammatory activity. The purpose of this work was to search for compounds possessing(More)
In previous experiments [I 3 ] we have established that amides of 2-chloro-, 2-hydrazino-, and 2-arylaminocinchoninic acid possess antiinflammatory and analgesic properties [l -3]. In continuation of that work, we have synthesized and characterized a series of substituted amides of 2-hydrazinocinchoninic acids, their derivatives with respect to the(More)
of diester (VIII) to considerably increase the locomotive activity and to improve the preservation of CRPA in rats. Further examination of the distinct antagonism of diester (XIII) to corazole is required, which makes it possible to assume that this compound has anticonvulsive properties, possibly as a result of antagonism to Glu. We may assume that the(More)