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The frequency distribution of deaths from cerebrovascular disease in England and Wales in 1975 by month of occurrence is described. The distribution is compared with that for related diseases, in particular ischaemic heart disease, hypertensive disease, pneumonia and bronchitis. The principal feature in all these diseases is high mortality in winter and(More)
An experiment is described which compared visual evoked potential (VEP) amplitudes and latencies in normal subjects and migraine patients. Several VEP abnormalities were found: at vertex and to a lesser extent at temporal sites, P100-N120 amplitudes were larger in patients; at vertex and temporal sites N120 amplitudes were larger in patients; at temporal(More)
Patients with dietary migraine were found to have significantly lower levels of platelet phenolsulphotransferase activity than either migrainous patients without a history of dietary provocation or normal controls. Of the two known human variants of this enzyme, the phenol-inactivating P form, for which no endogenous substrate has so far been identified,(More)
The effect of a 30 day course of corticotrophin gelatin injections on the natural history of acute unilateral optic neuritis in 27 patients is reported. A further 27 patients received inert injections in a double-blind control. Measurements were made on visual acuity, visual field, macular threshold, and colour vision, and the development of optic atrophy(More)
A double-blind cross-over trial between pheneturide and phenytoin in ninety-four outpatients with epilepsy is described. There was no significant difference between the frequency of seizures in the two groups. The difficulties in comparing two anticonvulsants of similar efficacy are discussed particularly in relation to ethical problems, the selection of(More)
Analysis of head movement during speech, monitored by the polarized light goniometer, showed that head movement accompanies speech almost continuously in a manner specific to the concomitant, suprasegmental speech features. Thus initiation of speech after long pauses was accompanied by wide, linear movements (PS). The termination of speech in a pause(More)