F. W. Schneider

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The transthyretin (TTR) amyloid diseases, representative of numerous misfolding disorders, are of considerable interest because there are mutations that cause or suppress disease. The Val30 --> Met30 (V30M) TTR mutation is the most prevalent cause of familial amyloid polyneuropathy in heterozygotes, whereas a Thr119 --> Met119 (T119M) mutation on the second(More)
The phospholipid headgroup mobility of small unilamellar vesicles composed of different mixtures of phosphatidyl-L-serine (PS) and phosphatidylcholine is characterized by the solvent relaxation behavior of the polarity sensitive dyes 6-propionyl-2-(dimethylamino)naphthalene (Prodan) and 6-palmitoyl-2-[trimethylammoniumethyl]-methylamino]naphthalene chloride(More)
A network of open, bistable reaction systems coupled by mass transfer is simulated. The mass transfer rates are determined by a Hebb-type rule, and the programmable network can store patterns of high and low concentrations in each bistable system. In a parallel computation, the network recognizes patterns similar, but not necessarily identical, to stored(More)
Kinetic and chromatographic analysis of cyclic nucleotide phosphodiesterase (EC 3.1.4.c) obtained from rat tissue has revealed that this enzyme exists in at least two molecular forms. After chromatographic separation, one form (cyclic AMP phosphodiesterase) still exhibits kinetics suggestive of the action of either two enzymes or one enzyme under negative(More)
The relative location, binding behaviour and the solvent relaxation behaviour of the polarity sensitive membrane probes 6-propionyl-2-(dimethylamino)naphthalene and 6-palmitoyl-2-[[trimethylammoniumethyl]methylamino]naphthalene chloride in vesicles composed of 1,2-dimyristoyl-sn-glycero-3-phosphatidylcholine or egg yolk lecithin have been compared using(More)
Time-resolved fluorescence measurements were performed for a set of n-anthroyloxy fatty acids (n-AS; n = 2, 3, 6, 9, 12, 16) in both solvent and vesicle systems. The Stokes' shifts and the mean relaxation times calculated from the time-resolved emission spectra (TRES) are shown to be strongly dependent on the position of the fluorophore in small unilamellar(More)
The solvent relaxation behavior of Patman (6-palmitoyl-2-[[2-(trimethylammonium) ethyl]methylamino]naphthalene chloride) was investigated in small unilamellar vesicles composed of symmetric diacyl( 1,2-dipalmitoylphosphatidylcholine; DPPC) and diether lipids (l,2-dihexadecylphosphatidylcholine; DHPC), calculating time-resolved emission spectra (TRES) and(More)
An exactly solvable model for single-molecule kinetics is suggested, based on the following assumptions: (i) A single molecule can exist in different chemical states and the random transitions from one chemical state to another can be described by a local master equation with time-dependent transition rates. (ii) Because of conformational and other(More)
Transthyretin (TTR) subunits were labeled with a charge-modifying tag to evaluate the possibility of subunit exchange between tetramers under physiological conditions. Starting with a mixture of two TTR homotetramers, one having all subunits tagged at the N termini and the other composed of untagged subunits, heterotetramer formation as a function of time(More)
A minimal mechanism is proposed which describes the transcriptional and translational processes for four phage proteins (RNA polymerase, DNase, primase and DNA polymerase) involved in T3/T7 DNA replication. Phage DNA replication is also included. It is shown how lag times may be incorporated into a kinetic mechanism. The distinct three-stage transport of(More)