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Therapy options at the time of recurrence of glioblastoma multiforme are often limited. We investigated whether treatment with a new intratumoral thermotherapy procedure using magnetic nanoparticles improves survival outcome. In a single-arm study in two centers, 66 patients (59 with recurrent glioblastoma) received neuronavigationally controlled(More)
The 1.06 micron Nd:YAG laser and a new fiberoptic delivery system, the Interstitial Thermo-Therapy (ITT) laser fibre, allows stereotactic interstitial irradiation of cerebral tumours. In experimental rat brain studies we found typical laser-tissue effects with a central necrosis and a sharply demarcated oedema towards the normal brain. The size of the(More)
LOCALITE is a frameless neuronavigation system that particularly addresses a problem with current i n terventional magnetic resonance imaging iMRI systems: non-interactive response time in the interactive scan mode and poor image quality with fast scanning sequences. LOCALITE calculates image planes selected via a handheld localizer from pre-or(More)
Tissue welding is a potentially important biomedical application of laser technology. The structural alterations basic to this phenomenon were studied in experimental repair of lesions of the rat carotid artery and sciatic nerve. A modified neodymiumdoped yttrium-aluminum-garnet laser operating at a wavelength of 1.319 micrometers was used in conjunction(More)
In contrast to the numerous publications on supratentorially located tuberculomas, reports on infratentorial tuberculomas, demonstrated by computed tomography, are relatively few in number. Although nowadays precise localization has become possible via computed tomography, a tuberculoma cannot be identified unequivocally by computed tomography. The(More)
One BCCA-phase (bilateral clamping of carotid arteria) leads to an extensive release of striatal dopamine with a subsequent formation of free radicals (Heim et al., 200b). Early investigations did not show histological damage to cerebral structures after 24 and 60 min duration of a BCCA phase (Melzacka et al., 1994). The study here turned out that oligemic(More)
OBJECTIVES To test the hypothesis that cortical plasticity related to destructive tumour growth is functionally relevant. This hypothesis predicts that function is dependent on the intactness of tissue surrounding the tumour. MATERIAL AND METHODS Eight patients underwent laser-induced interstitial thermotherapy (LITT) for minimally invasive palliative(More)
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