F Siani

Learn More
BACKGROUND The release of calcitonin gene-related peptide (CGRP) from trigeminal nerves plays a central role in the pathophysiology of migraine and clinical evidence shows an antimigraine effect for CGRP receptor antagonists. Systemic administration of nitroglycerin (NTG), a nitrovasodilator, consistently provokes spontaneous-like migraine attacks in(More)
BACKGROUND Constipation is extremely common in patients with Parkinson's disease (PD) and has been described in PD animal models. In this study, we investigated whether a PD-like degeneration of dopaminergic neurons of the substantia nigra can influence peristalsis in colonic segments of rats by impacting on enteric dopaminergic transmission. METHODS(More)
BACKGROUND Systemic nitroglycerin (NTG) activates brain nuclei involved in nociceptive transmission as well as in neuroendocrine and autonomic functions in rats. These changes are considered relevant for migraine because NTG consistently provokes spontaneous-like migraine attacks in migraineurs. Several studies have suggested a relationship between the(More)
Parkinson's disease (PD) is a neurodegenerative disease affecting the dopaminergic neurons of the substantia nigra. Aside from the central lesion, involvement of peripheral organs has been proposed as part of the complex clinical picture of the disease. The etiology is unknown in the majority of cases. Mitochondria and oxidative stress seem to play an(More)
  • 1