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Perhaps more than any other "-omics" endeavor, the accuracy and level of detail obtained from mapping the major connection pathways in the living human brain with diffusion MRI depend on the capabilities of the imaging technology used. The current tools are remarkable; allowing the formation of an "image" of the water diffusion probability distribution in(More)
Slice-selective RF waveforms that mitigate severe B1+ inhomogeneity at 7 Tesla using parallel excitation were designed and validated in a water phantom and human studies on six subjects using a 16-element degenerate stripline array coil driven with a butler matrix to utilize the eight most favorable birdcage modes. The parallel RF waveform design applied(More)
RATIONALE AND OBJECTIVES A cardiac imaging pilot study was performed on 1.5 and 3.0 Tesla (T) whole body magnetic resonance units equipped with identical gradient sets and geometrically equivalent body coils. The goals were to compare the signal-to-noise (SNR) and contrast-to-noise (CNR) ratios on matched studies conducted at both field strengths and(More)
Spatially selective RF waveforms were designed and demonstrated for parallel excitation with a dedicated eight-coil transmit array on a modified 3T human MRI scanner. Measured excitation profiles of individual coils in the array were used in a low-flip-angle pulse design to achieve desired spatial target profiles with two- (2D) and three-dimensional (3D)(More)
An eight-rung, 3T degenerate birdcage coil (DBC) was constructed and evaluated for accelerated parallel excitation of the head with eight independent excitation channels. Two mode configurations were tested. In the first, each of the eight loops formed by the birdcage was individually excited, producing an excitation pattern similar to a loop coil array. In(More)
Chemical shift imaging benefits from signal-to-noise ratio (SNR) and chemical shift dispersion increases at stronger main field such as 7 Tesla, but the associated shorter radiofrequency (RF) wavelengths encountered require B1+ mitigation over both the spatial field of view (FOV) and a specified spectral bandwidth. The bandwidth constraint presents a(More)
At high magnetic field, B(1)(+) non-uniformity causes undesired inhomogeneity in SNR and image contrast. Parallel RF transmission using tailored 3D k-space trajectory design has been shown to correct for this problem and produce highly uniform in-plane magnetization with good slice selection profile within a relatively short excitation duration. However, at(More)
Introduction: While increasing the number of array elements appears beneficial for both parallel transmission and reception, this approach is limited in practice, especially in the parallel transmit (pTX) case. Forming linear combinations of array elements can transform the spatial modes of the array into a different basis set, potentially capturing a(More)
Introduction At high magnetic field strength, B1 inhomogeneity causes undesired non-uniformity in SNR and contrast. Parallel RF design methods based on small flip angle approximation with " spoke "-based trajectories have been shown to correct this problem and produce highly uniform slice selective excitation with relatively short excitation durations(More)