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Cloned cDNAs have been isolated that encode a variant of hirudin, a potent thrombin inhibitor that is secreted by the salivary glands of the medicinal leech, Hirudo medicinalis. This variant probably… Continue Reading
The recent molecular cloning of factor VIII (FVIII or antihaemophilic factor)1–3 has brought new hope to haemophilia A patients of a safer therapeutic preparation. The choice of a host cell for the… Continue Reading
A unique 52mer oligonucleotide deduced from the amino acid sequence of bovine Factor IX was synthesized and used as a probe to screen a human liver cDNA bank. The Factor IX clone isolated shows 5… Continue Reading
Cloned cDNAs have been isolated that encode a variant of hirudin, a potent thrombin inhibitor that is secreted by the salivary glands of the medicinal leech, Hirudo medicinals. This variant probably… Continue Reading