F. S. Robscheit-Robbins

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Liver extracts are of peculiar interest at this time because of the keen clinical interest in the diet therapy of pernicious anemia. The liver fraction which has been studied with greatest care is that known as liver extract, No. 343, N.N.R., prepared by Eli Lilly and Company under the supervision of the Committee on Pernicious Anemia of the Harvard Medical(More)
In long continued severe anemia due to bleeding in dogs we may observe all degrees of red marrow spread. The maximal red marrow spread takes in the total marrow area in ribs, vertebrae and long bones. The minimal red marrow spread may involve but 10 to 20 per cent of this maximal area. All gradations between these extremes are observed in this series. The(More)
Experimental Conditions By G. H. TISHKOFF, Pit.I)., F. S. R0BScIIEIT-RoBBINs, Pii.D. AND 0. H. WIIIPPLE, M.D. I N THE ABUNDANT LITERATURE related to the red blood cell, one finds relatively few papers dealing with the st-roma residue. Method difficulties are largely responsible. It is certain, however, that the stroma fraction is of the utmost. importance,(More)
The immediate objective of these experiments is the best possible substitute or supplement for plasma or whole blood as used in the clinic to combat shock, post-operative difficulties, and lack of absorption from the gastro-intestinal tract. The long term objective is a better understanding of the utilization and replacement of the blood proteins and their(More)
Dogs with sustained anemia and hypoproteinemia due to bleeding and a continuing low protein or protein-free diet with abundant iron will continue to produce much new hemoglobin and plasma protein for many weeks. The stimulus of double depletion (anemia and hypoproteinemia) leads to raiding of body and tissue protein to fill the demand for new hemoglobin and(More)
The two preceding papers on red cell stroma furnish the necessary background for the use of vitamin BI~ with radioactive cobalt. I The most active red cell stroma production is found during the 3 to 4 days after the red cells emerge from the bone marrow (second paper). I t has been shown that in active regeneration the red cells remain about 3 to 4 days in(More)
Infection in human cases is often believed to be responsible for anemia. It is generally believed that lack of absorption and definite blood destruction are responsible for the anemia. Accelerated metabolism due to thyroid or dinitrophenol does not modify hemoglobin production in these standard anemic dogs. Endometritis lasting over many weeks will(More)
Given healthy dogs, fed abundant iron and protein-free or low protein diets, with sustained anemia due to bleeding, we can study the capacity of these animals to produce simultaneously new hemoglobin and plasma protein. The reserve stores of blood protein producing materials in this way are very largely depleted, and levels of 6 to 8 gm. per cent for(More)
Hemoglobin and globin alone, supplemented, or modified in various ways are seriously considered as plasma substitutes. Human globin given to doubly depleted (anemic and hypoproteinemic) dogs by vein contributes to the production of new hemoglobin and plasma protein, but there is some toxicity and weight loss. Dog hemoglobin given intraperitoneally is better(More)
Spontaneous glomerulonephritis develops not infrequently (11 per cent incidence) in the anemia colony. The course of the nephritis is insidious and usually extends over several years but ends in uremia, often with terminal bronchopneumonia. Hemoglobin production in these standard anemic dogs is well established as related to various standard food factors.(More)