F. S. Robscheit-Robbins

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Liver extracts are of peculiar interest at this time because of the keen clinical interest in the diet therapy of pernicious anemia. The liver fraction which has been studied with greatest care is that known as liver extract, No. 343, N.N.R., prepared by Eli Lilly and Company under the supervision of the Committee on Pernicious Anemia of the Harvard Medical(More)
In long continued severe anemia due to bleeding in dogs we may observe all degrees of red marrow spread. The maximal red marrow spread takes in the total marrow area in ribs, vertebrae and long bones. The minimal red marrow spread may involve but 10 to 20 per cent of this maximal area. All gradations between these extremes are observed in this series. The(More)
The two preceding papers on red cell stroma furnish the necessary background for the use of vitamin BI~ with radioactive cobalt. I The most active red cell stroma production is found during the 3 to 4 days after the red cells emerge from the bone marrow (second paper). It has been shown that in active regeneration the red cells remain about 3 to 4 days in(More)
Dogs with sustained anemia and hypoproteinemia due to bleeding and a continuing low protein or protein-free diet with abundant iron will continue to produce much new hemoglobin and plasma protein for many weeks. The stimulus of double depletion (anemia and hypoproteinemia) leads to raiding of body and tissue protein to fill the demand for new hemoglobin and(More)
Given healthy dogs, fed abundant iron and protein-free or low protein diets, with sustained anemia due to bleeding, we can study the capacity of these animals to produce simultaneously new hemoglobin and plasma protein. The reserve stores of blood protein producing materials in this way are very largely depleted, and levels of 6 to 8 gm. per cent for(More)
Biological assay of the human liver in various types of anemia shows conspicuous differences in the concentration of hemoglobin producing factors. Pernicious anemia shows very high values and the liver in untreated cases may show maximal storage of the hemoglobin producing factors. Liver therapy reduces this store as the missing factor is supplied and new(More)
When we first took up the study of the hemoglobin production factors in abnormal livers, we were surprised to find that the great majority of these cases showed normal or perhaps low normal human values. It is obvious from a glance at the tables below that only under conditions of grave injury does the liver cell give up the unknown substances which can be(More)