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Little is known about spinal visceral reflexes in brain-dead man, although they have been described in experimental animals. In 1983, 25 brain-dead individuals were observed during donor nephrectomy. It was confirmed that some of these donors, without higher centre modulation and not under significant pharmacological influence, had viscero-somatic motor(More)
The effects of 142 intravenous boluses of althesin (0.05 ml/kg) on cerebral perfusion pressure (CPP) were studied in twelve head injured comatose patients. The data were divided into those where the mean pre-bolus intracranial pressure (ICP) was above or below 20 mmHg and then subdivided into those where the minimum pre-bolus voltage of the cerebral(More)
Biopsy material from human gliomas obtained during neurosurgery was used to investigate whether pathological human brain tissue is capable of producing kynurenic acid (KYNA), a natural brain metabolite which can act as an antagonist at excitatory amino acid receptors. Upon in vitro exposure to 40, 200 or 1000 microM L-kynurenine, the immediate bioprecursor(More)
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