F Prielmeier

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BACKGROUND AND PURPOSE Diffusion-weighted MRI can demonstrate decreases of the apparent diffusion coefficient (ADC) of brain tissue water shortly after the onset of ischemia. To further elucidate underlying mechanisms, this study extended diffusion assessment to intracellular metabolites in rat brain in vivo before, during, and after ischemia. METHODS(More)
Oxygenation-sensitive MRI of respiratory challenges in the brain of experimental animals will considerably benefit from a quantitative relationship between cerebral blood oxygenation and MRI parameters. Here, a multi-echo gradient-echo MRI technique was used to determine effective transverse relaxation rates R2* = 1/T2* of rat brain in vivo during short(More)
Transient alterations in brain oxygenation during 60-s periods of anoxia were visualized at high spatial resolution (voxel size < or = 0.15 microliter) with the use of serial long echo time FLASH (fast low-angle shot) magnetic resonance images (measuring time > or = 6 s) of halothane-anesthetized rats in vivo. Difference images from normoxia and anoxia(More)
Localized proton NMR spectroscopy was used to dynamically monitor alterations of cerebral metabolites before, during, and after a 10 min period of global forebrain ischemia in anesthetized rats. Metabolic assessment was based on user-independent determination of absolute brain concentrations at a nominal temporal resolution of 1.6 min. While the(More)
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