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Hepatitis delta antigen (HDAg), the only protein encoded by the hepatitis delta virus (HDV), binds specifically genomic and antigenomic strands of the HDV RNA. In a previous study, three recombinant HDAg subdomains were synthesized, covering residues 11 to 78, 79 to 163 and 164 to 212, and only the middle domain was shown to be responsible for the binding(More)
Hepatitis delta virus (HDV) packaging requires prenylation of the HDV large protein (p27), as well as a direct protein-protein interaction between HDV proteins and hepatitis B virus (HBV) envelope protein domains. To investigate this interaction, we have analysed the binding capacity of baculovirus-expressed delta p24 and p27 proteins to synthetic peptides(More)
Very few studies were devoted to permanent effects of nocturnal railway noise on sleep and cardiovascular reactivity. We investigated the effects of nocturnal railway noise on sleep and cardiovascular response in young and middle-aged adults living for many years either near a railway track or in a quiet area. Forty subjects (50% males) divided into two age(More)
The detection of multicomponent signals for which the components are not equidetectable is precisely investigated as a function of the level difference ΔL(i∕j) between components. The detection thresholds are determined for a seven-tone complex signal with random starting phases masked by white noise. Level differences between the components are examined. A(More)
There are few information at French railway station. People have to take attention to the visual sign to get the information of train departure time, corridor number, change the train etc. However, some stations of SNCF, which is the national railway company, are very large and have many lines, for instance, TGV, domestic, international line, so that it(More)
Après avoir longtemps travaillé sur le confort acoustique des voyageurs en gare, la SNCF souhaite désormais évaluer l'apport du design sonore. L'objectif du travail présenté ici est alors de proposer des solutions de design sonore pour l'amélioration de l'usage d'une gare. Ce travail a été effectué en collaboration étroite avec l'équipe Perception et Design(More)
This article introduces a new method for localizing high-speed moving sources with a microphone array followed by a chirplet transform. A well-adapted chirplet is constructed and the accuracy of the method is studied within a general case. Simulations and real data from the high-speed train (Train a Grande Vitesse), are compared with the current(More)
En parallèle des travaux sur le confort acoustique des voyageurs en gare, la SNCF souhaite aussi évaluer l'apport du design sonore. L'objectif du travail présenté ici est alors de proposer des solutions de design sonore pour l'amélioration de l'usage d'une gare. Ce travail a été effectué en collaboration étroite avec l'équipe Perception et Design Sonores de(More)
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