F. P. Gerstheimer

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The distribution of calcitonin gene-related peptide like-immunoreactivity (CGRP-IR) within the heart and adjacent blood vessels of the guinea pig was investigated anmunohistochemically by use of the peroxidase-antiperoxidase (PAP) technique. Numerous paravascular and perivascular immunoreactive nerve fibers were localized around the aorta, coronary arteries(More)
A computer-assisted method is introduced for the morphometric analysis of immunoreactive markers of the innervation of the heart, such as synaptophysin, neuropeptide Y (NPY), neurotensin (NT), substance P (SP), and calcitonin gene-related peptide (CGRP). Video images of stained sections were digitalized and the area density (AD) of the immunoreactive(More)
The distribution of synaptophysin, an integral polypeptide of presynaptic vesicle membranes, was investigated in guinea pig heart by immunohistochemistry using monoclonal antibodies. Synaptophysin immunoreactivity was found in varicose nerve terminals in all regions of the heart. Dense networks of immunoreactive varicosities were found to surround the(More)
Distribution and amount of neuropeptide Y- and synaptophysin-immunoreactive nervous structures within the heart were investigated in dogs 4 days after ligation of the left anterior descending coronary artery (LAD). In the right atrium and posterior left ventricular regions, which were taken as (non-infarcted) control areas, neuropeptide Y-immunoreactive(More)
The effects of cardiac sympathetic overactivity on spontaneous arrhythmias and transmural left ventricular effective refractory period (LVERP) were assessed by left stellate stimulation (LSS) in 16 anesthetized dogs. The experiments were performed 4 days after proximal occlusion of the left anterior descending (LAD) coronary artery produced by either(More)
Cl− efflux into various incubation media (PSS) was studied in pieces of rabbit aortae loaded with36Cl. Replacement of HCO 3 − /CO2 by HEPES/O2 in the PSS increased the rate of Cl− efflux by a factor of 2.4. This effect was suppressed in Cl−-free PSS containing isethionate, propionate, or benzenesulfonate, but not in NO 3 − -PSS, or Br−-PSS. The stimulant(More)
MECHANISMS OF VASODILATATION G. Haeusler The u l t ima te f ac to r tha t regu la tes tone of vascular smooth muscle (VSM) appears to be the concent ra t ion of i n t r a c e l lular free Ca ions, often referred to as activator Ca. In VSM activator Ca stems from both external and internal sources. It enters the cells from outside through potential and/or(More)
In v.s.m, from rabbi ts , I mM furosemide immediately interferes with the steady state exchange of Cl(CI-SSE) by 41%. Prolonged incubation with furosemide reduces CIi by 51% thereby establ ishing a C l i /C l o ra t i o compatible with a passive d i s t r i bu t ion , and increases the membrane potent ial by 5.5 mV evidencing the existence of an act ive(More)
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