F. N. C. Krijzer

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The preparation of an isolated hemisected spinal cord preparation, maintained in vitro, from mature (180-300 g body weight) rats is described. Sacral and coccygeal segments (S2-Co1) gave consistent ventral root reflexes (DR-VRP) from electrical stimulation of dorsal roots. The mean latency and amplitude of the fastest component in the ventral root reflex,(More)
Freely moving rats were implanted with cortical, caudal, thalamic, and reticular electrodes. Drugs were infused intravenously at a constant rate up to a final cumulative dose of 40, 50, or 60 mg/kg. Doses of 10 mg/kg imipramine, viloxazine, desmethylimipramine, mianserin, and maprotiline produced spike-wave complexes, spikes, and increased spindling.(More)
The action of central depressant drugs (CDD) was investigated on the electrical activity of the cerebellum (CB) and/or red nucleus (RN). They can be divided into different groups according to their effect on the cerebello-rubral system: 1. Classical hypnotics (barbiturates, paraldehyde, chloral hydrate, piperidinedione derivatives, methaqualone, ethinamate,(More)
The effects of a number of psycho-active drugs on electrocorticographic activity (ECoG) of the rat have been studied. Frontoparietal ECoG was recorded during 6-min periods immediately before drug/vehicle administration and starting at 20 and 45 min after administration. For each 6-min recording time, a mean power spectrum was calculated and smoothed. A(More)
A mature sacrococcygeal in vitro spinal preparation from the rat has been used to demonstrate effects of neutral amino acids and their antagonists. gamma-Aminobutanoate (GABA), glycine and taurine (0.5-5 mM) produced dose-dependent depression of spontaneous paroxysmal activity generated in Mg2+ -free medium. The depressant effect of GABA was antagonised(More)
EEG recordings from 5 different brain areas of freely moving rats were performed under controlled vigilance stage conditions. Effects of antidepressant and neuroleptic drugs were assessed following their intraperitoneal injection. Quantification of the drug effects was achieved by analysis of variance following on-line fast-Fourier transformation of the EEG(More)
Electroencephalograms were recorded from the parietal and frontal cortex of freely moving rats held in constant vigilance by placing them in a slowly turning drum. The effects of 5 clinically effective anxiolytics, buspirone, meprobamate, phenobarbital, chlordiazepoxide and diazepam, were studied after intraperitoneal injection of different doses. After(More)
The effects of drugs on electrocorticographic activity (ECoG) of the rat are studied in a routine screen. ECoG is recorded for 6-min periods before drug/vehicle administration and starting at 20 and 45 min thereafter. For each period, a mean power spectrum is calculated. Drugs are tested in 25 rats according to a 5 x 5 Latin square design and effects are(More)
The aim of the study was to detect whether antidepressants cause specific EEG effects in rats. The results presented are based on quantitative evaluation of a series of 6-min vigilance-controlled EEG recordings in rats under standardized conditions. Standard conditions comprised: a vigilance control, a rigid test procedure in which drugs and rats are(More)