F. Moreno

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Hexokinase 2 is an essential factor for signalling repression through the Saccharomyces cerevisiae high-glucose sensing pathway. The main regulatory mechanism that controls the HXK2 gene expression in yeast is mediated by the Rgt1 and Med8 transcription factors, which repress HXK2 expression in low-glucose containing media. In this study, we show that the(More)
Hkx2 (hexokinase 2) from Saccharomyces cerevisiae was one of the first metabolic enzymes described as a multifunctional protein. Hxk2 has a double subcellular localization: it functions as a glycolytic enzyme in the cytoplasm and as a regulator of gene transcription of several Mig1-regulated genes in the nucleus. To get more insights into the(More)
In the presence of glucose the protein hexokinase 2 (Hxk2p), normally resident in the cytosol, is translocated to the nucleus where it impairs the activation of transcription of the glucose-repressed genes HXK1, GLK1 and SUC2, and promotes the activation of transcription of the glucose-induced genes HXK2 and HXT1. Here, we demonstrate the involvement of an(More)
PURPOSE To identify tissue microRNAs predictive of sunitinib activity in patients with metastatic renal-cell-carcinoma (MRCC) and to evaluate in vitro their mechanism of action in sunitinib resistance. METHODS We screened 673 microRNAs using TaqMan Low-density-Arrays (TLDAs) in tumors from MRCC patients with extreme phenotypes of marked efficacy and(More)
The multilingual soil profile database (named SDBm Plus) is user-friendly software designed to store and retrieve in an efficient and systematic way the large amounts of geo-referenced soil attribute data collected in soil surveys and laboratories. The database has the following main characteristics: (i) running on Windows platforms; (ii) 'assist menus'(More)
the intensity statistics of the s-polarized electromagnetic field scattered from randomly rough, perfectly conducting, one-dimensional surfaces are studied in the case of surface transverse correlation lengths larger than the wavelength. In particular, the speckle contrast, the intensity probability-density function, and the mean scattered intensity are(More)
Mig2 has been described as a transcriptional factor that in the absence of Mig1 protein is required for glucose repression of the SUC2 gene. Recently it has been reported that Mig2 has two different subcellular localizations. In high-glucose conditions it is a nuclear modulator of several Mig1-regulated genes, but in low-glucose most of the Mig2 protein(More)
The structure of the aerosol layers in the Great Red Spot (GRS) of Jupiter is investigated from high-quality CCD ground-based observations. The observation of the feature was made at a variety of wavelengths at UV through the near-infrared and at different observational geometries as the large oval rotated from the central meridian to the limb, and at(More)