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The mechanisms involved in the progression from monoclonal gammopathy of undetermined significance (MGUS) and smoldering myeloma (SMM) to malignant multiple myeloma (MM) and plasma cell leukemia (PCL) are poorly understood but believed to involve the sequential acquisition of genetic hits. We performed exome and whole-genome sequencing on a series of MGUS(More)
In order to maintain cellular homeostasis, excess or misfolded proteins must be removed and/or recycled. 1 In myeloma, plasma cells produce large quantities of immunoglobulin, and excess unfolded immunoglobulin results in high levels of endoplasmic reticulum (ER) stress. These proteins are removed either via the proteasome 2 or via autophagy, 3 suggesting(More)
MMSET is the key molecular target in t(4;14) myeloma The t(4;14)(p16.3;q32.3) is found in 15% of presenting multiple myeloma (MM) cases and is associated with a significantly worse prognosis than other biological subgroups. As a consequence of the translocation, two genes are aberrantly expressed, the fibroblast growth factor receptor 3 (FGFR3) and a(More)
To evaluate the relationship between inflammatory markers and severity of asthma in children, the amount of interleukin-8 (IL-8) and granulocyte/macrophage colony-stimulating factor (GM-CSF) released by peripheral blood mononuclear cells, exhaled nitric oxide (FE NO) levels, p65 nuclear factor-kappaB subunit, and phosphorylated IkBalpha expression by(More)
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