F Melanthiou

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Somatic frameshift mutations in exon 9 of the calreticulin (CALR) gene were recently identified in patients with BCR-ABL-negative myeloproliferative neoplasms (MPNs), particularly essential thrombocythemia and myelofibrosis. 1,2 Calreticulin is a highly conserved endoplasmic reticulum (ER) luminal Ca 2 þ-binding chaperone protein with a critical role in the(More)
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