F-M Ng

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OBJECTIVE A recent genome-wide association study identified a locus within natriuretic peptide receptor C (NPR3) to be significantly associated with blood pressure (BP), To functionally characterise the effect of BP- associated SNPs (single nucleotide polymorphisms) at the NPR3 locus in the context of BP regulatory pathways(Figure is included in full-text(More)
OBJECTIVE hSLC39A8 (human solute carrier family 39 member 8) encodes a transmembrane protein that co-transports divalent heavy metal cations, such as Cd2+, with elusive physiological role. Recent genome-wide association studies have identified a non-synonymous single nucleotide polymorphism rs13107325 to be associated with hypertension. To investigate the(More)
BACKGROUND AND PURPOSE N-methyl-D-aspartate (NMDA) receptors represent an attractive drug target for the treatment of neurological and neurodegenerative disorders associated with glutamate-induced excitotoxicity. The aim of this study was to map the binding domain of high affinity 5-substituted benzimidazole derivatives(More)
Background and purpose: N-methyl-D-aspartate (NMDA) receptors represent an attractive drug target for the treatment of neurological and neurodegenerative disorders associated with glutamate-induced excitotoxicity. The aim of this study was to map the binding domain of high affinity 5-substituted benzimidazole derivatives(More)
OBJECTIVE Genomewide-association studies have identified a number of loci influencing blood pressure, one of which is located near SLC4A7 (lead SNP rs13082711). SLC4A7 encodes an electroneutral Na+, HCO3- co-transporter, NBCn1, which contributes to intracellular pH (pHi) regulation in a range of tissues, including vascular smooth muscle and endothelium.(More)
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