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Repeated intratracheal (IT) inoculation of rabbits with a homogenized, saline suspension of Micropolspora faeni produced bronchopulmonary (BP) histologic lesions resembling those of human hypersensitivity pneumonitis. With an in vitro phagocytic and bactericidal assay, an analysis of BP macrophages from M. faeni-injected rabbits demonstrated activation at(More)
In June, 36 lizards (males and females) were injected with 0.01, 0.1, 1.0, 10.0, or 100 mg/kg of MIF-I, or the diluent vehicle, and placed in a cage for ten minutes. Tonic immobility (TI) was then induced on an open lab table. All doses of MIF-I significantly reduced TI duration as compared to the duration with the diluent alone. In subsequent experiments(More)
Animals sensitized by intratracheal administration of particulate Micropolyspora faeni antigen and subsequently challenged with the antigen intratracheally developed lesions of hypersensitivity pneumonitis histologically similar to those observed in man wih this disease. Animals sensitized with antigen but depleted of complement with cobra venom factor(More)
Three experiments were done with the lizard, Anolis carolinensis, as a follow-up on our previous work which showed that MIF-I reduced tonic immobility (TI) during the breeding season and that females had longer TI durations than males in the non-breeding season. In June, during the breeding season, 60 male and 60 female lizards were injected with 0.1 mg/kg(More)
Rabbits were sensitized with Micropolyspora faeni by intratracheal inoculations and later challenged with the same antigen either with or without parenteral administration of cortisone acetate prior to challenge. Animals developed anti-M. faeni serum precipitins, M. faeni-induced alveolar macrophage migration inhibition, and positive 48-hr skin reactivity(More)
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