F Kanemura

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Taste signal transduction occurs in the microvillous membrane of taste cells. Previously, we hypothesized that c-GMP may mediate sweet taste transduction. Some data indicated that IP3 may have a role in vertebrate bitter taste transduction. Here we report that the different second messengers are activated by different tastes. We used techniques designed for(More)
The purpose of this study is whether the gustatory neural response of taste cell to a binary mixture with threshold concentration of acid becomes synergistic or antagonistic can be estimated from the whole chorda tympani (CT) nerve in the rat. The present data demonstrate that acids are synergistic enhancer for sugars, and suppressor for NaCl and QHCl, but(More)
The importance of taste and smell in discrimination of tastes was examined in normal and anosmic mice. We studied the influence of olfaction on taste sensation using behavioral and electrophysiological methods in both normal animals and animals made anosmic mice by destroying their olfactory receptor cells with zinc sulfate (ZnSO(4)) solution.(More)
The decline in olfaction with age is well documented in histological, psychological, and electroencephalographical studies. However, there are few electrophysiological studies on changes in the sensitivity of the peripheral olfactory cells with age. We evaluated the behavior, the amplitude of electro-olfactogram (EOG), and the thickness of the olfactory(More)
Mouse gustatory responses to sucrose, monellin and thaumatin were examined extracellularly from the chorda tympani nerve and intracellularly from individual taste receptor cells. Although monellin and thaumatin taste intensely sweet to humans and old-world monkeys, they do not appear to elicit chorda tympani nerve responses in rats and other mammals.(More)
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