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BACKGROUND The combination of a low pH and a high concentration of lactate which is present in most dialysis fluids is found to be cytotoxic in vitro. For these reasons it would seem logical to use a bicarbonate-containing solution and thus automatically provide a solution with a neutral pH. METHODS A parallel, randomized, open-label, prospective 2-month(More)
OBJECTIVE To evaluate the safety and efficacy of bicarbonate- and bicarbonate/lactate-based PD fluids. DESIGN A randomly allocated prospective controlled trial lasting eight weeks. SETTING Five renal units in Europe. PATIENTS Individuals who have been treated by CAPD for at least three months and who have had at least one month's therapy with 40(More)
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