Mice transgenic for human carcinoembryonic antigen as a model for immunotherapy.
- Patrick ClarkeJeffrey R. MannJean F. SimpsonKaren Rickard-DicksonF. PrimusF. Primus
- 1 April 1998
Medicine
CEA transgenic mice may serve as a useful model for studying the efficacy and safety of various immunotherapy strategies directed at this tumor self-antigen, and its properties in tissues of mice transgenic for the human CEA gene are similar to that observed in human tissues.
Use of radiolabeled antibodies to carcinoembryonic antigen for the detection and localization of diverse cancers by external photoscanning.
- D. GoldenbergF. Deland P. Rayburn
- 22 June 1978
Medicine
To determine whether tumors containing carcinoembryonic antigen could be detected by administration of a radiolabeled, affinity-purified, goat lgG, 18 patients with a history of cancer of diverse histopathology received an average total dose of 1.0 mCi of 131l-labeled lGG.
"Sandwich"-type immunoassay of carcinoembryonic antigen in patients receiving murine monoclonal antibodies for diagnosis and therapy.
- F. PrimusE A KelleyH. J. HansenD. M. Goldenberg
- 1 February 1988
Medicine
Measurements of carcinoembryonic antigen (CEA) in blood increased dramatically in some patients who were receiving injections of monoclonal antibody, accompanied by the appearance and coincident increase in titers of human antibody against mouse Ig (HAMA).
Immunocytochemical detection of carcinoembryonic antigen in conventional histopathology specimens
- D. GoldenbergR. SharkeyF. Primus
- 1 September 1978
Medicine
It is proposed that immunocytochemical staining of CEA in conventional tumor pathology sections can be used to discriminate those cases in which blood CEA titers need to be determined on a serial basis in order to monitor recurrence or progression, since a positive immunoperoxidase reaction forCEA in the primary tumor predicts well in many cases which patients will have aBlood CEA value reflecting disease activity.
Successful cancer vaccine therapy for carcinoembryonic antigen (CEA)‐expressing colon cancer using genetically modified dendritic cells that express CEA and T helper‐type 1 cytokines in CEA…
- T. OjimaM. Iwahashi H. Yamaue
- 1 February 2007
Medicine, Biology
This vaccination strategy resulted in the generation of highly efficient therapeutic immune responses against MC38‐CEA in the absence of autoimmune responses and demonstrated no adverse effects, and may therefore be useful for future clinical applications as a cancer vaccine therapy.
Serologic mapping and biochemical characterization of the carcinoembryonic antigen epitopes using fourteen distinct monoclonal antibodies
- M. KurokiJ. GreinerJ. SimpsonF. PrimusF. GuadagniJ. Schlom
- 15 August 1989
Biology, Medicine
A series of 14 monoclonal anti‐carcinoembryonic antigen antibodies that show a strong degree of selective reactivity for human colon carcinomas versus normal adult tissues were used to construct a serological map of the CEA molecule, showing that the COL‐reactive epitopes appear to be of a proteinaceous nature.
Photoscan localization of GW-39 tumors in hamsters using radiolabeled anticarcinoembryonic antigen immunoglobulin G.
- David M. GoldenbergPreston DfF. PrimusHans J. Hansen
- 1974
Biology, Medicine
It appears that CEA is a suitable tumor target for radioantibody by photoscanning, as it is found in CEA-producing GW-39 tumors treated with an anti-CEA antibody preparation, permits photoscan visualization of tumors too small to be demonstrated by radiolabeled normal IgG.
Radioimmunodetection of cancer with radioactive antibodies to carcinoembryonic antigen.
- D. GoldenbergE. KimF. DelandS. BennettF. Primus
- 1 August 1980
Medicine
Radioimmunodetection was more reliable in detecting cancer among the patient population studied than were the plasma CEA assay results, although in colorectal, cervical, and lung cancer patients there appeared to be a correlation between positive radioimmunoidetection and Plasma CEA elevation.
Carcinoembryonic antigen in histopathology: immunoperoxidase staining of conventional tissue sections.
- D. GoldenbergR. SharkeyF. Primus
- 1 July 1976
Medicine
Examination of 359 tissue specimens showed that CEA could usually be demonstrated in a group of cancers, and the threshold for CEA staining in malignant specimens was usually above that in nonmalignant specimens, while retrospective estimates of minimal tissue CEA concentrations in older histopathologic specimens by the immunoperoxidase reaction method were permitted.
Initial experience evaluating 90yttrium-radiolabeled anti-carcinoembryonic antigen chimeric T84.66 in a phase I radioimmunotherapy trial.
- J. WongL. Williams J. Shively
- 1 December 1995
Medicine
Its low immunogenicity after a single administration makes it attractive for further evaluation as a radioimmunotherapeutic agent, however, further evaluation is needed to determine whether its immunogensicity will remain low after multiple administrations.
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