F. J. Fitzpatrick

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This paper describes the ongoing development of a design assistant, RaPiD, for use in prosthetic dentistry. RaPiD integrates computed-aided design, knowledge-based systems and databases, employing a logic-based representation as the unifying medium. The user's manipulation of icons representing the developing design is interpreted as a set of transactions(More)
Interest in the field of neuroimmunoendocrinology is in full expansion. With regard to this, steroid influence on the immune system, in particular sex steroids and glucocorticoids, has been known for a long time. Sex steroids are part of the mechanism underlying the immune sexual dimorphism, as particularly emphasized in autoimmune diseases.(More)
The multi-domain enzyme phenylalanine hydroxylase (PAH) catalyzes the hydroxylation of dietary I-phenylalanine (Phe) to I-tyrosine. Inherited mutations that result in PAH enzyme deficiency are the genetic cause of the autosomal recessive disorder phenylketonuria. Phe is the substrate for the PAH active site, but also an allosteric ligand that increases(More)
Conversion of vitamin B12 (cobalamin, Cbl) into the cofactor forms methyl-Cbl (MeCbl) and adenosyl-Cbl (AdoCbl) is required for the function of two crucial enzymes, mitochondrial methylmalonyl-CoA mutase and cytosolic methionine synthase, respectively. The intracellular proteins MMACHC and MMADHC play important roles in processing and targeting the Cbl(More)
Classic galactosemia is a potentially lethal disease caused by the dysfunction of galactose 1-phosphate uridylyltransferase (GALT). Over 300 disease-associated GALT mutations have been reported, with the majority being missense changes, although a better understanding of their underlying molecular effects has been hindered by the lack of structural(More)
This study illustrates how retention models can be used to accurately predict the retention behaviour of polydisperse macromolecules in LC separations. It highlights that the number of experiments required can be drastically reduced when the relationship between the model parameters and molecular structure parameters (e.g. molar mass) can be incorporated(More)
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