F. J. C. Smith

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23 24 Purpose: Telaprevir is a hepatitis C virus protease inhibitor that is both a substrate and 25 an inhibitor of CYP3A. Amlodipine and atorvastatin are both substrates of CYP3A and 26 are amongst the drugs most frequently used by patients with hepatitis C. This study was 27 conducted to examine the effect of telaprevir on atorvastatin and amlodipine 28(More)
In this open-label study, 24 healthy volunteers received a single intravenous (IV) dose of 0.5 mg of midazolam on day 1 and a single oral dose each of 2 mg of midazolam and 0.5 mg of digoxin on day 3. Telaprevir 750 mg every 8 hours was administered from day 8 through day 23, along with a single IV dose of 0.5 mg of midazolam on day 17 and single oral doses(More)
AIM To evaluate the effects of ketoconazole, rifampicin and efavirenz on the pharmacokinetics of telaprevir in healthy volunteers. METHOD Results from three clinical studies are described. (1) Volunteers received a single 750 mg dose telaprevir with and without a single 400 mg dose ketoconazole. (2) Volunteers received (a) 1250 mg telaprevir followed by(More)
PURPOSE "Code Blue" is a standard term used to alertt hospital staff that a patient requires resuscitation. This study determined rates of survival from Code Blue events and the role of opioids and other factors on survival. METHODS Data derived from medical records and the Code Blue and Pharmacy databases were analyzed for factors affecting survival. (More)
1. 244 albino rats from standard Wistar Institute stock have been kept for periods up to 72 days under the following conditions. (a) Barometric pressure: 3040 mm. Hg. This means a partial pressure of oxygen of 635 mm. Hg and is equivalent to an 83.6 per cent oxygen mixture at normal barometric pressure. (b) Temperature: 28 degrees C. (c) Humidity: 50 per(More)
BACKGROUND Diarrhea because of Salmonella infection is a cause of neonatal calf diarrhea. The stimulation of passive immunity in the calf by vaccinating the dam for Salmonella has shown some success in previous studies; however, there are no data on the use of currently licensed vaccines in the United States. OBJECTIVE To determine whether vaccinating(More)
BACKGROUND An intravenous (IV) overdose of pentobarbital sodium is the most commonly used method of euthanasia in veterinary medicine. However, this compound is not available in many countries or rural areas resulting in usage of alternative methods such as intrathecal lidocaine administration after IV anesthesia. Its safety and efficacy as a method of(More)
1. Pulmonary arterial hypertension was demonstrated in a series of rats that had been kept for 24-31 days in an environment of compressed air, having a barometric pressure of 3040 mm. Hg. The partial pressure of oxygen was 635 mm. Hg, which is equivalent to an 83.6 per cent oxygen mixture at normal barometric pressure. 2. Sclerosing changes in the pulmonary(More)
BACKGROUND Intrathecal lidocaine hydrochloride under general anesthesia has been used as an alternative method of euthanasia in equids. Carnivore, scavenger, and even human consumption of horse meat from carcasses have been anecdotally reported in rural areas after this method of euthanasia. The presence of drug residues in horse meat has not been(More)